ArticleBiophysical journal2012
Measuring Ca2+-induced structural changes in lipid monolayers: implications for synaptic vesicle exocytosis.
Article in Biophysical journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed.
- Synapsin shields a lipid monolayer from interactions with vesicles and associated structural rearrangements.Biophysical journal · 2026Article
- Ionic Liquid-Induced Phase-Separated Domains in Lipid Multilayers Probed by X-ray Scattering Studies.ACS omega · 2021Article
- Probing the effect of a room temperature ionic liquid on phospholipid membranes in multilamellar vesicles.European biophysics journal : EBJ · 2019Article
- Thermodynamics of interaction of ionic liquids with lipid monolayer.Biophysical reviews · 2018Review
- Counterion-mediated cluster formation by polyphosphoinositides.Chemistry and physics of lipids · 2014Review
- Studying calcium-triggered vesicle fusion in a single vesicle-vesicle content and lipid-mixing system.Nature protocols · 2013Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synaptic vesicles (SVs) are small, membrane-bound organelles that are found in the synaptic terminal of neurons. Although tremendous progress has been made in understanding the protein machinery that drives fusion of SVs with the presynaptic membrane, little progress has been made in understanding changes in the membrane structure that accompany this process. We used lipid monolayers of defined composition to mimic biological membranes, which were probed by x-ray reflectivity and grazing incidence x-ray diffraction. These techniques allowed us to successfully monitor structural changes in the membranes at molecular level, both in response to injection of SVs in the subphase below the monolayer, as well as to physiological cues involved in neurotransmitter release, such as increases in the concentration of the membrane lipid PIP(2), or addition of physiological levels of Ca(2+). Such structural changes may well modulate vesicle fusion in vivo.
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Registered trials
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