ArticleBiophysical journal2012
Three-dimensional analysis of the effect of epidermal growth factor on cell-cell adhesion in epithelial cell clusters.
Article in Biophysical journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 33 citations in OpenAlex.
- Emergent depth-mechanosensing of epithelial collectives regulates cell clustering and dispersal on layered matrices.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Epifluorescence-based three-dimensional traction force microscopy.Scientific reports · 2020Article
- Measuring mechanical stress in living tissues.Nature reviews. Physics · 2020Article
- Mechanophenotyping of 3D multicellular clusters using displacement arrays of rendered tractions.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Substrate curvature induces fallopian tube epithelial cell invasion via cell-cell tension in a model of ovarian cortical inclusion cysts.Integrative biology : quantitative biosciences from nano to macro · 2019Article
- Three-Dimensional Monolayer Stress Microscopy.Biophysical journal · 2019Article
- Collective Cell Behavior in Mechanosensing of Substrate Thickness.Biophysical journal · 2018Article
- Measuring mechanodynamics in an unsupported epithelial monolayer grown at an air-water interface.Molecular biology of the cell · 2017Article
- Microbuckling of fibrin provides a mechanism for cell mechanosensing.Journal of the Royal Society, Interface · 2015Article
- Engineering cell-cell signaling.Current opinion in biotechnology · 2013Review
- Cadherin-based intercellular adhesions organize epithelial cell-matrix traction forces.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Monolayer stress microscopy: limitations, artifacts, and accuracy of recovered intercellular stresses.PloS one · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
The effect that growth factors such as epidermal growth factor (EGF) have on cell-cell adhesion is of interest in the study of cellular processes such as epithelial-mesenchymal transition. Because cell-cell adhesions cannot be measured directly, we use three-dimensional traction force microscopy to measure the tractions applied by clusters of MCF-10A cells to a compliant substrate beneath them before and after stimulating the cells with EGF. To better interpret the results, a finite element model, which simulates a cluster of individual cells adhered to one another and to the substrate with linear springs, is developed to better understand the mechanical interaction between the cells in the experiments. The experiments and simulations show that the cluster of cells acts collectively as a single unit, indicating that cell-cell adhesion remains strong before and after stimulation with EGF. In addition, the experiments and model emphasize the importance of three-dimensional measurements and analysis in these experiments.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.