ArticleBiophysical journal2012
Cardiac cellular coupling and the spread of early instabilities in intracellular Ca2+.
Article in Biophysical journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Simultaneous Widefield Voltage and Dye-Free Optical Mapping Quantifies Electromechanical Waves in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.ACS photonics · 2023Article
- OptoGap is an optogenetics-enabled assay for quantification of cell-cell coupling in multicellular cardiac tissue.Scientific reports · 2021Article
- Cardiac Alternans: Mechanisms and Clinical Utility in Arrhythmia Prevention.Journal of the American Heart Association · 2019Review
- Cardiomyocyte-myofibroblast contact dynamism is modulated by connexin-43.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Dynamics of spatiotemporal line defects and chaos control in complex excitable systems.Scientific reports · 2017Article
- Restitution characteristics of His bundle and working myocardium in isolated rabbit hearts.PloS one · 2017Article
- Optical control of excitation waves in cardiac tissue.Nature photonics · 2015Article
- Cardiac myocyte alternans in intact heart: Influence of cell-cell coupling and β-adrenergic stimulation.Journal of molecular and cellular cardiology · 2015Article
- Myocardial electrotonic response to submaximal exercise in dogs with healed myocardial infarctions: evidence for β-adrenoceptor mediated enhanced coupling during exercise testing.Frontiers in physiology · 2015Article
- Spatiotemporal dynamics of calcium-driven cardiac alternans.Physical review. E, Statistical, nonlinear, and soft matter physics · 2014Article
- A translational approach to probe the proarrhythmic potential of cardiac alternans: a reversible overture to arrhythmogenesis?American journal of physiology. Heart and circulatory physiology · 2014Review
- Decoding myocardial Ca²⁺ signals across multiple spatial scales: a role for sensitivity analysis.Journal of molecular and cellular cardiology · 2013Review
- The effects of the histone deacetylase inhibitor 4-phenylbutyrate on gap junction conductance and permeability.Frontiers in pharmacology · 2013Article
- Computational approaches to understand cardiac electrophysiology and arrhythmias.American journal of physiology. Heart and circulatory physiology · 2012Review
- Intracellular calcium signals display an avalanche-like behavior over multiple lengthscales.Frontiers in physiology · 2012Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Recent experimental and modeling studies demonstrate the fine spatial scale, complex nature, and independent contribution of Ca(2+) dynamics as a proarrhythmic factor in the heart. The mechanism of progression of cell-level Ca(2+) instabilities, known as alternans, to tissue-level arrhythmias is not well understood. Because gap junction coupling dictates cardiac syncytial properties, we set out to elucidate its role in the spatiotemporal evolution of Ca(2+) instabilities. We experimentally perturbed cellular coupling in cardiac syncytium in vitro. Coupling was quantified by fluorescence recovery after photobleaching, and related to function, including subtle fine-scale Ca(2+) alternans, captured by optical mapping. Conduction velocity and threshold for alternans monotonically increased with coupling. Lower coupling enhanced Ca(2+) alternans amplitude, but the spatial spread of early (<2 Hz) alternation was the greatest under intermediate (not low) coupling. This nonmonotonic relationship was closely matched by the percent of samples exhibiting large-scale alternans at higher pacing rates. Computer modeling corroborated these experimental findings for strong but not weak electromechanical (voltage-Ca(2+)) coupling, and offered mechanistic insight. In conclusion, using experimental and modeling approaches, we reveal a general mechanism for the spatial spread of subtle cellular Ca(2+) alternans that relies on a combination of gap-junctional and voltage-Ca(2+) coupling.
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