ArticleBiophysical journal2012
Random hydrolysis controls the dynamic instability of microtubules.
Article in Biophysical journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Lattice instability drives formation of protofilament clusters at the microtubule plus-end tips.Biophysical journal · 2026Article
- Hydrolysis-dependent severing tunes internal monomeric heterogeneity to shape actin length distributions.bioRxiv : the preprint server for biology · 2025Article
- Physical effects of crowdant size and concentration on collective microtubule polymerization.Biophysical journal · 2025Article
- EB3-informed dynamics of the microtubule stabilizing cap during stalled growth.Biophysical journal · 2025Article
- Minimal Mechanisms of Microtubule Length Regulation in Living Cells.Bulletin of mathematical biology · 2024Article
- The effect of motor-induced shaft dynamics on microtubule stability and length.Biophysical journal · 2023Article
- Effects of random hydrolysis on biofilament length distributions in a shared subunit pool.Biophysical journal · 2022Article
- Effects of length-dependent positive feedback on length distributions of microtubules undergoing hydrolysis.Journal of biosciences · 2022Article
- Atomistic molecular dynamics simulations of tubulin heterodimers explain the motion of a microtubule.European biophysics journal : EBJ · 2021Article
- Spatio-temporal correlations between catastrophe events in a microtubule bundle: a computational study.European biophysics journal : EBJ · 2020Article
- Behaviors of individual microtubules and microtubule populations relative to critical concentrations: dynamic instability occurs when critical concentrations are driven apart by nucleotide hydrolysis.Molecular biology of the cell · 2020Article
- Article
- Mechanisms of kinetic stabilization by the drugs paclitaxel and vinblastine.Molecular biology of the cell · 2017Article
- Signatures of a macroscopic switching transition for a dynamic microtubule.Scientific reports · 2017Article
- Review
- Article
- Molecular and Mechanical Causes of Microtubule Catastrophe and Aging.Biophysical journal · 2015Article
- Regulation of Microtubule Growth and Catastrophe: Unifying Theory and Experiment.Trends in cell biology · 2015Review
- Force-induced dynamical properties of multiple cytoskeletal filaments are distinct from that of single filaments.PloS one · 2014Article
- Microtubule dynamic instability: a new model with coupled GTP hydrolysis and multistep catastrophe.BioEssays : news and reviews in molecular, cellular and developmental biology · 2013Article
Corrections and comments
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Uncovering mechanisms that control the dynamics of microtubules is fundamental for our understanding of multiple cellular processes such as chromosome separation and cell motility. Building on previous theoretical work on the dynamic instability of microtubules, we propose here a stochastic model that includes all relevant biochemical processes that affect the dynamics of microtubule plus-end, namely, the binding of GTP-bound monomers, unbinding of GTP- and GDP-bound monomers, and hydrolysis of GTP monomers. The inclusion of dissociation processes, present in our approach but absent from many previous studies, is essential to guarantee the thermodynamic consistency of the model. Our theoretical method allows us to compute all dynamic properties of microtubules explicitly. Using experimentally determined rates, it is found that the cap size is ∼3.6 layers, an estimate that is compatible with several experimental observations. In the end, our model provides a comprehensive description of the dynamic instability of microtubules that includes not only the statistics of catastrophes but also the statistics of rescues.
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