ArticleBiophysical journal2012
Response to a pure tone in a nonlinear mechanical-electrical-acoustical model of the cochlea.
Article in Biophysical journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Gating-spring stiffness increases outer-hair-cell bundle stiffness, damping, and receptor current.Scientific reports · 2024Article
- 3D morphology of an outer-hair-cell hair bundle increases its displacement and dynamic range.Biophysical journal · 2024Article
- Broad nonlinearity in reticular lamina vibrations requires compliant organ of Corti structures.Biophysical journal · 2023Article
- An outer hair cell-powered global hydromechanical mechanism for cochlear amplification.Hearing research · 2022Article
- Analysis of outer hair cell electromechanics reveals power delivery at the upper-frequency limits of hearing.Journal of the Royal Society, Interface · 2022Article
- The origin of mechanical harmonic distortion within the organ of Corti in living gerbil cochleae.Communications biology · 2021Article
- A role for tectorial membrane mechanics in activating the cochlear amplifier.Scientific reports · 2020Article
- Diverse Mechanisms of Sound Frequency Discrimination in the Vertebrate Cochlea.Trends in neurosciences · 2020Review
- Periodicity Pitch Perception.Frontiers in neuroscience · 2020Article
- Unified cochlear model for low- and high-frequency mammalian hearing.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Power Dissipation in the Cochlea Can Enhance Frequency Selectivity.Biophysical journal · 2019Article
- A Bundle of Mechanisms: Inner-Ear Hair-Cell Mechanotransduction.Trends in neurosciences · 2019Review
- Timing of the reticular lamina and basilar membrane vibration in living gerbil cochleae.eLife · 2018Article
- Forward and Reverse Waves: Modeling Distortion Products in the Intracochlear Fluid Pressure.Biophysical journal · 2018Article
- Modeling Pitch Perception With an Active Auditory Model Extended by Octopus Cells.Frontiers in neuroscience · 2018Article
- Cochlear Outer-Hair-Cell Power Generation and Viscous Fluid Loss.Scientific reports · 2016Article
- Reverse transduction measured in the living cochlea by low-coherence heterodyne interferometry.Nature communications · 2016Article
- Intracochlear Scala Media Pressure Measurement: Implications for Models of Cochlear Mechanics.Biophysical journal · 2015Article
- Article
- Effect of the attachment of the tectorial membrane on cochlear micromechanics and two-tone suppression.Biophysical journal · 2014Article
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2 authors.
Funding
Abstract
In this article, a nonlinear mathematical model is developed based on the physiology of the cochlea of the guinea pig. The three-dimensional intracochlear fluid dynamics are coupled to a micromechanical model of the organ of Corti and to electrical potentials in the cochlear ducts and outer hair cells (OHC). OHC somatic electromotility is modeled by linearized piezoelectric relations whereas the OHC hair-bundle mechanoelectrical transduction current is modeled as a nonlinear function of the hair-bundle deflection. The steady-state response of the cochlea to a single tone is simulated in the frequency domain using an alternating frequency time scheme. Compressive nonlinearity, harmonic distortion, and DC shift on the basilar membrane (BM), tectorial membrane (TM), and OHC potentials are predicted using a single set of parameters. The predictions of the model are verified by comparing simulations to available in vivo experimental data for basal cochlear mechanics. In particular, the model predicts more amplification on the reticular lamina (RL) side of the cochlear partition than on the BM, which replicates recent measurements. Moreover, small harmonic distortion and DC shifts are predicted on the BM, whereas more significant harmonic distortion and DC shifts are predicted in the RL and TM displacements and in the OHC potentials.
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