ReviewCurrent opinion in chemical biology2012
Biocatalysts and small molecule products from metagenomic studies.
Review in Current opinion in chemical biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- Microbial Blue Bioprospecting: Exploring the Advances of Compounds Post-Discovery.Marine drugs · 2025Review
- High-Throughput Mining of Novel Compounds from Known Microbes: A Boost to Natural Product Screening.Molecules (Basel, Switzerland) · 2024Review
- Bioprospecting the microbiome of Red Sea Atlantis II brine pool for peptidases and biosynthetic genes with promising antibacterial activity.Microbial cell factories · 2022Article
- The role of soils in provision of genetic, medicinal and biochemical resources.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- A Novel VIII Carboxylesterase with High Hydrolytic Activity Against Ampicillin from a Soil Metagenomic Library.Molecular biotechnology · 2019Article
- Phylogenomic Analysis of β-Lactamase in Archaea and Bacteria Enables the Identification of Putative New Members.Genome biology and evolution · 2018Article
- Identification of the Colicin V Bacteriocin Gene Cluster by Functional Screening of a Human Microbiome Metagenomic Library.ACS infectious diseases · 2018Article
- Bacterial natural product biosynthetic domain composition in soil correlates with changes in latitude on a continent-wide scale.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Functional metagenomics reveals novel β-galactosidases not predictable from gene sequences.PloS one · 2017Article
- Natural Product Discovery through Improved Functional Metagenomics in Streptomyces.Journal of the American Chemical Society · 2016Article
- Metagenomic discovery of novel enzymes and biosurfactants in a slaughterhouse biofilm microbial community.Scientific reports · 2016Article
- Culture-independent discovery of natural products from soil metagenomes.Journal of industrial microbiology & biotechnology · 2016Review
- Culture-independent method for identification of microbial enzyme-encoding genes by activity-based single-cell sequencing using a water-in-oil microdroplet platform.Scientific reports · 2016Article
- Quorum sensing is a language of chemical signals and plays an ecological role in algal-bacterial interactions.Critical reviews in plant sciences · 2016Article
- Emerging concepts promising new horizons for marine biodiscovery and synthetic biology.Marine drugs · 2015Review
- A novel psychrophilic alkaline phosphatase from the metagenome of tidal flat sediments.BMC biotechnology · 2015Article
- Inhibition of the growth of Bacillus subtilis DSM10 by a newly discovered antibacterial protein from the soil metagenome.Bioengineered · 2015Article
- Structural and biochemical characterization of a metagenome-derived esterase with a long N-terminal extension.Protein science : a publication of the Protein Society · 2015Article
- Rational and combinatorial tailoring of bioactive cyclic dipeptides.Frontiers in microbiology · 2015Review
- Antibacterial enzymes from the functional screening of metagenomic libraries hosted in Ralstonia metallidurans.FEMS microbiology letters · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The vast majority of bacteria present in environmental samples have never been cultured and therefore have not been exploited for the ability to produce useful biocatalysts or collections of biocatalysts generating interesting small molecules. Metagenomic libraries constructed using DNA extracted directly from natural bacterial communities offer access to the genetic information present in the genomes of these as yet uncultured bacteria. This review highlights recent efforts to recover both discrete enzymes and small molecules from metagenomic libraries.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.