ReviewReproductive biology and endocrinology : RB&E2012
hCG, the wonder of today's science.
Review in Reproductive biology and endocrinology : RB&E, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
75 citing papers in PubMed, 1 synthesis or guideline pooled it, 196 citations in OpenAlex.
- Translational interdisciplinary research on human chorionic gonadotropin's enhancement of neuroendocrine crosstalk: a novel medical hypothesis for systemic adjunctive treatment of psychiatric disorders.Frontiers in psychiatry · 2025Pooled it
- Competence of Combined Low Dose of Human Chorionic Gonadotropin (HCG) and Clomiphene Citrate (CC) Versus Continued CC during Ovulation Induction in Women with CC-Resistant Polycystic Ovarian Syndrome: A Randomized Controlled Trial.Medicina (Kaunas, Lithuania) · 2024Trial
- Compact dual-channel visible-light fluorescence endoscope for real-time molecular imaging: system design and validation in ectopic pregnancy tissue.Biomedical optics express · 2026Article
- Unexpected elevation of β-hCG in EGFR-mutant lung adenocarcinoma: a case study and implications for clinical practice.BMC pulmonary medicine · 2026Article
- LK-1: an investigational therapy targeting hCG-β in metastatic breast, bladder, ovarian, and cervical cancers.Scientific reports · 2026Article
- The β-hCG-TNF-α-T cell axis in threatened abortion: unraveling the pathogenic cascade from aberrant glycosylation to inflammatory demise.Frontiers in immunology · 2026Review
- LHCGR phamacodynamic effects during follicular maturation.Frontiers in endocrinology · 2026Review
- Neuroendocrine crosstalk between sex and metabolic hormones: mechanisms and implications across the female reproductive spectrum.Discover endocrinology and metabolism · 2026Review
- The role of luteinizing hormone in the management of female infertility: A French Delphi consensus.Journal of assisted reproduction and genetics · 2025Article
- Structure of an LGR dimer, an evolutionary predecessor of glycoprotein hormone receptors.Nature communications · 2025Article
- The Role of β-Core Fragment hCG in Embryo Implantation and Early Pregnancy.International journal of molecular sciences · 2025Article
- Article
- Nanoflow Size Exclusion Chromatography-Native Mass Spectrometry of Intact Proteoforms and Protein Complexes.Analytical chemistry · 2025Article
- Discovery of potential small molecule inhibitors against β-hCG: anRSC advances · 2025Article
- Are We Estimating the Mean and Variance Correctly in the Presence of Observations Outside of Measurable Range?Pharmacology research & perspectives · 2025Article
- Secretion of placental peptide hormones: functions and trafficking.Frontiers in endocrinology · 2025Review
- Multiplying Meanings of Pregnancy Through Personal Accounts of Gestational Trophoblastic Disease.Body & society · 2024Article
- Article
- Serum β-hCG as a Biomarker in Pancreatic Neuroendocrine Tumors: Rethinking Single-Analyte Approach.Cancers · 2024Article
- Aberrant trophoblastic differentiation in human cancer: An emerging novel therapeutic target (Review).Oncology reports · 2024Review
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundhCG is a wonder. Firstly, because hCG is such an extreme molecule. hCG is the most acidic glycoprotein containing the highest proportion of sugars. Secondly, hCG exists in 5 common forms. Finally, it has so many functions ranging from control of human pregnancy to human cancer. This review examines these molecules in detail. CONTENT: These 5 molecules, hCG, sulfated hCG, hyperglycosylated hCG, hCG free beta and hyperglycosylated free beta are produced by placental syncytiotrophoblast cells and pituitary gonadotrope cells (group 1), and by placental cytotrophoblast cells and human malignancies (group 2). Group 1 molecules are both hormones that act on the hCG/LH receptor. These molecules are central to human menstrual cycle and human pregnancy. Group 2 molecules are autocrines, that act by antagonizing a TGF beta receptor. These molecules are critical to all advanced malignancies.
conclusionsThe hCG groups are molecules critical to both the molecules of pregnancy or human life, and to the advancement of cancer, or human death.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.