ArticleVeterinary research2012
Relationship between susceptibility of Blackface sheep to Teladorsagia circumcincta infection and an inflammatory mucosal T cell response.
Article in Veterinary research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Secretory IgA as Biomarker for Gastrointestinal Nematodes Natural Infection in Different Breed Sheep.Animals : an open access journal from MDPI · 2023Article
- Vaccine-induced time- and age-dependent mucosal immunity to gastrointestinal parasite infection.NPJ vaccines · 2022Article
- Variants Within GenesFrontiers in genetics · 2022Article
- Infection with the sheep gastrointestinal nematode Teladorsagia circumcincta increases luminal pathobionts.Microbiome · 2020Article
- Resistance to Haemonchus contortus in Corriedale sheep is associated to high parasite-specific IgA titer and a systemic Th2 immune response.Scientific reports · 2019Article
- Identification of appropriate reference genes for local immune-related studies in Morada Nova sheep infected with Haemonchus contortus.Molecular biology reports · 2018Article
- A candidate gene approach to study nematode resistance traits in naturally infected sheep.Veterinary parasitology · 2017Article
- Evaluating Stress Physiology and Parasite Infection Parameters in the Translocation of Critically Endangered Woylies (Bettongia penicillata).EcoHealth · 2017Article
- Transcriptomic Study on Ovine Immune Responses to Fasciola hepatica Infection.PLoS neglected tropical diseases · 2016Article
- Mucosal Expression of T Cell Gene Variants Is Associated with Differential Resistance to Teladorsagia circumcincta.PloS one · 2016Article
- Article
- The host immune response to gastrointestinal nematode infection in sheep.Parasite immunology · 2015Review
- Variable exon usage of differentially-expressed genes associated with resistance of sheep to Teladorsagia circumcincta.Veterinary parasitology · 2015Article
- A joint analysis to identify loci underlying variation in nematode resistance in three European sheep populations.Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2014Article
- Functional investigation of a QTL affecting resistance to Haemonchus contortus in sheep.Veterinary research · 2014Article
- The Differentiation of CD4(+) T-Helper Cell Subsets in the Context of Helminth Parasite Infection.Frontiers in immunology · 2014Review
- Current status for gastrointestinal nematode diagnosis in small ruminants: where are we and where are we going?Journal of immunology research · 2014Review
- Exploring the abomasal lymph node transcriptome for genes associated with resistance to the sheep nematode Teladorsagia circumcincta.Veterinary research · 2013Article
- The immunology and genetics of resistance of sheep to Teladorsagia circumcincta.Veterinary research communications · 2013Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Teladorsagia circumcincta is the most economically important gastrointestinal (abomasal) nematode parasite of sheep in cool temperate regions, to which sheep show genetically-varying resistance to infection. Lambs, from parents with genetic variation for resistance, were trickle infected with L3 larvae over 12 weeks. 45 lambs were identified with a range of susceptibilities as assessed by: adult worm count at post mortem, faecal egg count (FEC) and IgA antibody levels. This project investigated the correlation of T cell cytokine expression and resistance to infection at the mature stage of response, when the resistant lambs had excluded all parasites.Histopathology showed only minor changes in resistant animals with a low level lymphocyte infiltration; but in susceptible lambs, major pathological changes were associated with extensive infiltration of lymphocytes, eosinophils and neutrophils.Absolute quantitative RT-qPCR assays on the abomasal lymph node (ALN) revealed a significant positive correlation between IL6, IL21 and IL23A transcript levels with adult worm count and FEC. IL23A was also negatively correlated with IgA antibody levels. Significantly positive correlation of TGFB1 levels with adult worm count and FEC were also seen in the abomasal mucosa. These data are consistent with the hypothesis that the inability to control L3 larval colonization, adult worm infection and egg production is due to the activation of the inflammatory Th17 T cell subset.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.