ArticleClinical science (London, England : 1979)2012
Ubiquitin-proteasome system inhibitors and AMPK regulation in hepatic cold ischaemia and reperfusion injury: possible mechanisms.
Article in Clinical science (London, England : 1979), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Static Cold Storage and Machine Perfusion: Redefining the Role of Preservation and Perfusate Solutions.International journal of molecular sciences · 2025Review
- CircRNA-Phf21a_0002 promotes pyroptosis to aggravate hepatic ischemia/ reperfusion injury by sponging let-7b-5p.Heliyon · 2024Article
- AMPK-mTOR-ULK1-mediated autophagy protects carbon tetrachloride-induced acute hepatic failure by inhibiting p21 in rats.Journal of toxicologic pathology · 2021Article
- Fenofibrate Ameliorates Hepatic Ischemia/Reperfusion Injury in Mice: Involvements of Apoptosis, Autophagy, and PPAR-PPAR research · 2021Article
- Preservation Solutions for Kidney Transplantation: History, Advances and Mechanisms.Cell transplantation · 2019Review
- The Relevance of the UPS in Fatty Liver Graft Preservation: A New Approach for IGL-1 and HTK Solutions.International journal of molecular sciences · 2017Article
- Relevance of proteolysis and proteasome activation in fatty liver graft preservation: An Institut Georges Lopez-1World journal of gastroenterology · 2017Article
- Melatonin role preventing steatohepatitis and improving liver transplantation results.Cellular and molecular life sciences : CMLS · 2016Review
- Effects of Institut Georges Lopez-1 and Celsior preservation solutions on liver graft injury.World journal of gastroenterology · 2015Article
- Cold ischemia-induced autophagy in rat lung tissue.Molecular medicine reports · 2015Article
- Emerging concepts in liver graft preservation.World journal of gastroenterology · 2015Review
- Role of AMP-activated protein kinase in cross-talk between apoptosis and autophagy in human colon cancer.Cell death & disease · 2014Article
- Liver autophagy: much more than just taking out the trash.Nature reviews. Gastroenterology & hepatology · 2014Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the present Hypothesis article, we summarize and present data from the literature that support our hypothesis on the potential mechanisms by which UPS (ubiquitin-proteasome system) inhibitors reduce I/R (ischaemia/reperfusion) injury in the liver. I/R is the main cause of primary liver failure and, consequently, minimizing the detrimental effects of this process could increase the number of suitable transplantation grafts and also enhance the survival rate of patients after liver transplantation. A potential strategy to reduce I/R injury is the use of UPS inhibitors either as additives to preservation solutions or as drugs administered to patients. However, there is still controversy over whether the use of UPS inhibitors is beneficial or deleterious with regard to liver injury. From our experience and the few studies that have investigated the role of UPS in hepatic I/R, we believe that the use of UPS inhibitors is a potential strategy to reduce I/R injury in liver transplantation and graft preservation. We hypothesize that one of the main mechanisms of action of UPS inhibitors may be the up-regulation of AMPK (AMP-activated protein kinase) activity and the consequent down-regulation of mTOR (mammalian target of rapamycin), which may finally influence autophagy and preserve the energy state of the cell.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.