ArticleJournal of addiction research & therapy2011
Neurophysiology of Nicotine Addiction.
Article in Journal of addiction research & therapy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Exenatide once weekly for smoking cessation: study protocol for a randomized clinical trial.Medicine · 2018Trial
- Suspected nicotine-induced acute urticaria following excessive use of smoking cessation lozenges: a case report.Frontiers in medicine · 2026Article
- Does perceived vaping addiction predict subsequent vaping cessation behaviour among adults who use nicotine vaping products regularly?Addictive behaviors · 2025Article
- Adolescent nicotine administration increases nicotinic acetylcholine receptor binding and functional connectivity in specific cortico-striatal-thalamic circuits.Brain communications · 2022Article
- Substance abuse and neurotransmission.Advances in pharmacology (San Diego, Calif.) · 2022Article
- Dynamic associations between anxiety, depression, and tobacco use in older adults: Results from The Irish Longitudinal Study on Ageing.Journal of psychiatric research · 2021Article
- Recent findings in the pharmacology of inhaled nicotine: Preclinical and clinical in vivo studies.Neuropharmacology · 2020Review
- Sex differences in cholinergic systems in the interpeduncular nucleus following nicotine exposure and withdrawal.Neuropharmacology · 2019Article
- Menthol facilitates dopamine-releasing effect of nicotine in rat nucleus accumbens.Pharmacology, biochemistry, and behavior · 2018Article
- HIV, Tat and dopamine transmission.Neurobiology of disease · 2017Review
- Nicotine regulates activity of lateral habenula neurons via presynaptic and postsynaptic mechanisms.Scientific reports · 2016Article
- Molecular Mechanism: ERK Signaling, Drug Addiction, and Behavioral Effects.Progress in molecular biology and translational science · 2016Review
- Nicotine and Resting-State Functional Connectivity: Effects of Intermittent Doses.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2015Article
- Factors Associated With Smoking Status among HIV-Positive Patients in Routine Clinical Care.Journal of AIDS & clinical research · 2015Article
- Varenicline enhances dopamine release facilitation more than nicotine after long-term nicotine treatment and withdrawal.Pharmacology research & perspectives · 2015Article
- Finding genomic function for genetic associations in nicotine addiction research: the ENCODE project's role in future pharmacogenomic analysis.Pharmacology, biochemistry, and behavior · 2014Article
- Neurocognitive endophenotypes in schizophrenia: modulation by nicotinic receptor systems.Progress in neuro-psychopharmacology & biological psychiatry · 2014Review
- Cholinergic transmission during nicotine withdrawal is influenced by age and pre-exposure to nicotine: implications for teenage smoking.Developmental neuroscience · 2014Article
- Intravenous nicotine injection induces rapid, experience-dependent sensitization of glutamate release in the ventral tegmental area and nucleus accumbens.Journal of neurochemistry · 2013Article
- Effects of VMAT2 inhibitors lobeline and GZ-793A on methamphetamine-induced changes in dopamine release, metabolism and synthesis in vivo.Journal of neurochemistry · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Tobacco use is a major health problem, and nicotine is the main addictive component. Nicotine binds to nicotinic acetylcholine receptors (nAChR) to produce its initial effects. The nAChRs subtypes are composed of five subunits that can form in numerous combinations with varied functional and pharmacological characteristics. Diverse psychopharmacological effects contribute to the overall process of nicotine addiction, but two general neural systems are emerging as critical for the initiation and maintenance of tobacco use. Mesocorticolimbic circuitry that includes the dopaminergic pathway originating in the ventral tegmental area and projecting to the nucleus accumbens is recognized as vital for reinforcing behaviors during the initiation of nicotine addiction. In this neural system β2, α4, and α6 are the most important nAChR subunits underlying the rewarding aspects of nicotine and nicotine self-administration. On the other hand, the epithalamic habenular complex and the interpeduncular nucleus, which are connected via the fasciculus retroflexus, are critical contributors regulating nicotine dosing and withdrawal symptoms. In this case, the α5 and β4 nAChR subunits have critical roles in combination with other subunits. In both of these neural systems, particular nAChR subtypes have roles that contribute to the overall nicotine addiction process.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.