ArticleAutoimmune diseases2012
Introducing polyautoimmunity: secondary autoimmune diseases no longer exist.
Article in Autoimmune diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers, 2 of them syntheses that pooled it.
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Who cites it
94 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Novel risk factors for cardiovascular disease in rheumatoid arthritis.Immunologic research · 2013Pooled it
- How do autoimmune diseases cluster in families? A systematic review and meta-analysis.BMC medicine · 2013Pooled it
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- Autoantibody signatures in children with celiac disease, juvenile idiopathic arthritis, and polyautoimmunity.JPGN reports · 2026Article
- Osimertinib, a Trigger of Subacute Cutaneous Lupus Erythematosus: Three-Patient Case Series and Literature Review.Clinical, cosmetic and investigational dermatology · 2026Article
- Development of a novel flow cytometry multiplex immunoassay for the diagnosis of celiac disease simultaneously with autoimmune diabetes.European journal of medical research · 2025Article
- Silicone Breast Implants and Autoimmunity: A case report.JPRAS open · 2025Article
- Polyautoimmunity Reflecting Immune Dysregulation in Common Variable Immunodeficiency.Biomedicines · 2025Article
- Criteria and non-criteria anti-phospholipid antibodies in the different clinical forms of antiphospholipid syndrome.Frontiers in immunology · 2025Article
- Endocrine polyautoimmunity: Mechanistic insights and the future of AI-driven diagnostics.EXCLI journal · 2025Review
- Large-scale global retrospective study on the interaction between ancestry and risk of comorbid autoimmune diseases in patients with pemphigus.Scientific reports · 2024Article
- Circulating Autoantibodies in Adults with Hashimoto's Thyroiditis: New Insights from a Single-Center, Cross-Sectional Study.Diagnostics (Basel, Switzerland) · 2024Article
- Hypophysitis and central nervous system involvement in association with Sjögren's syndrome along with hypoparathyroidism: a case report.BMC neurology · 2024Article
- Co-existence of ANCA-associated vasculitides with immune-mediated diseases: a single-center observational study.Rheumatology international · 2024Observational
- Inflammatory Bowel Disease-Associated Arthritis Is Associated with Concomitant Autoimmune and Inflammatory Disorders.Digestive diseases and sciences · 2024Article
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- Analysis of theInternational journal of molecular sciences · 2024Article
- Ocular cicatricial pemphigoid: is there an association with autoimmune diseases?International ophthalmology · 2024Article
34 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Similar pathophysiological mechanisms within autoimmune diseases have stimulated searches for common genetic roots. Polyautoimmunity is defined as the presence of more than one autoimmune disease in a single patient. When three or more autoimmune diseases coexist, this condition is called multiple autoimmune syndrome (MAS). We analyzed the presence of polyautoimmunity in 1,083 patients belonging to four autoimmune disease cohorts. Polyautoimmunity was observed in 373 patients (34.4%). Autoimmune thyroid disease (AITD) and Sjögren's syndrome (SS) were the most frequent diseases encountered. Factors significantly associated with polyautoimmunity were female gender and familial autoimmunity. Through a systematic literature review, an updated search was done for all MAS cases (January 2006-September 2011). There were 142 articles retrieved corresponding to 226 cases. Next, we performed a clustering analysis in which AITD followed by systemic lupus erythematosus and SS were the most hierarchical diseases encountered. Our results indicate that coexistence of autoimmune diseases is not uncommon and follows a grouping pattern. Polyautoimmunity is the term proposed for this association of disorders, which encompasses the concept of a common origin for these diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.