ArticleExperimental diabetes research2012
Association of FTO polymorphisms with early age of obesity in obese Italian subjects.
Article in Experimental diabetes research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Macronutrients and the FTO gene expression in hypothalamus; a systematic review of experimental studies.Indian heart journalPooled it
- Influence of FTO rs9939609 and Mediterranean diet on body composition and weight loss: a randomized clinical trial.Journal of translational medicine · 2018Trial
- A complete linkage disequilibrium in a haplotype of three SNPs in Fat Mass and Obesity associated (FTO) gene was strongly associated with anthropometric indices after controlling for calorie intake and physical activity.BMC medical genetics · 2018Trial
- A haplotype of three SNPs in FTO had a strong association with body composition and BMI in Iranian male adolescents.PloS one · 2018Trial
- Associations of the FTO rs9939609 and the MC4R rs17782313 polymorphisms with type 2 diabetes are modulated by diet, being higher when adherence to the Mediterranean diet pattern is low.Cardiovascular diabetology · 2012Trial
- Interaction Effects ofGenes · 2024Article
- Genetic association ofJournal of cardiovascular and thoracic research · 2024Article
- Initial Weight Loss, Anthropometric Parameters, and Proinflammatory Transcript Levels in Patients with Class I Obesity.Biomedicines · 2023Article
- Differential Association of FTO Gene variants and Haplotypes with the Susceptibility to Polycystic Ovary Syndrome According To Obesity in Women with PCOS.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- Review
- Unraveling the Complex Interactions between the Fat Mass and Obesity-Associated (FTO) Gene, Lifestyle, and Cancer.Advances in nutrition (Bethesda, Md.) · 2022Review
- Article
- Nutrigenetic variants and response to diet/lifestyle intervention in obese subjects: a pilot study.Acta diabetologica · 2022Article
- Role of FTO and MC4R Polymorphisms in Escalating Obesity and Their Indirect Association With Risk of T2D in Indian Population.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2020Article
- Genetic variants in the fat mass and obesity-associated (FTO) gene confer risk for extreme obesity and modulate adiposity in a Brazilian population.Genetics and molecular biology · 2020Article
- The association of the fat mass and obesity-associated gene (FTO) rs9939609 polymorphism and the severe obesity in a Brazilian population.Diabetes, metabolic syndrome and obesity : targets and therapy · 2019Article
- Common FTO rs9939609 variant and risk of type 2 diabetes in Palestine.BMC medical genetics · 2018Article
- Association of FTO rs9939609 with Obesity in the Kuwaiti Population: A Public Health Concern?Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2018Article
- The (FTO) gene polymorphism is associated with metabolic syndrome risk in Egyptian females: a case- control study.BMC medical genetics · 2017Article
- Impact of FTO SNPsArchives in cancer research · 2017Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity is recognized as a major health problem worldwide. Genetic factors play a major role in obesity, and genomewide association studies have provided evidence that several common variants within the fat mass- and obesity-associated (FTO) gene are significantly associated with obesity. Very limited data is available on FTO in the Italian population. Aims of our study are to investigate: (1) the association of FTO gene SNPs rs9939609 and rs9930506 with body mass index (BMI) and obesity-related parameters in a large cohort (n = 752) of Italian obese subjects; (2) the association between the two FTO SNPs and age of onset of obesity. Our results demonstrate a strong association between FTO SNPs rs9939609 (P < 0.043) and rs9930506 (P < 0.029) with BMI in the Italian population. FTO rs9930506 was significantly associated with higher BMI in a G allele dose-dependent manner (BMI + 1.4 kg/m² per G allele). We also observed that the association with BMI of the two FTO variants varied with age, with the carriers of the risk alleles developing an increase in body weight earlier in life. In conclusion, our study further demonstrates a role of the genetic variability in FTO on BMI in a large Italian population.
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