ArticleFrontiers in neural circuits2012
Vestibular and attractor network basis of the head direction cell signal in subcortical circuits.
Article in Frontiers in neural circuits, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.
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Who cites it
85 citing papers in PubMed.
- Trial
- Head direction cells use a head-referenced dual-axis updating rule in 3D space.Communications biology · 2026Article
- Neural circuit models for evidence accumulation through choice-selective sequences.Nature communications · 2026Article
- A single dose of ethanol in adult mice transiently alters the organization of spontaneous exploratory behaviors in a dark open field.Alcohol (Fayetteville, N.Y.) · 2026Article
- Medial entorhinal VIP-expressing interneurons receive input from the thalamic anterior dorsal nucleus and are critical for spatial memory.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The head-direction signal is generated from two types of head direction cells in brainstem nuclei.Nature communications · 2025Article
- Trans-Synaptic Virus Tracing Reveals Reciprocal Connections of the Interpeduncular Nucleus With the Mood, Exteroceptive, Interoceptive, and Motor Control Systems.The Journal of comparative neurology · 2025Article
- Encoding of interdependent features of head direction and angular head velocity in navigation.PNAS nexus · 2025Article
- Distinct subnetworks of the mouse anterior thalamic nuclei.Nature communications · 2025Article
- Unsupervised Phenotyping Reveals Disrupted Neural Firing Characteristics in the Anterior Thalamus and Surrounding Brain Regions Following Third-Trimester Equivalent Alcohol Exposure in Mice.bioRxiv : the preprint server for biology · 2025Article
- Harnessing a noncanonical vestibular input in the head-direction network to rectify age-related navigational deficits.Nature aging · 2025Article
- Task demands influence search strategy selection in otoconia-deficient mice.Frontiers in neurology · 2025Article
- Evolutionarily conserved brainstem architecture enables gravity-guided vertical navigation.PLoS biology · 2024Article
- Intrinsic Bipolar Head-Direction Cells in the Medial Entorhinal Cortex.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Comparison of head direction cell firing characteristics across thalamo-parahippocampal circuitry.Hippocampus · 2024Article
- Dopamine receptors of the rodent fastigial nucleus support skilled reaching for goal-directed action.Brain structure & function · 2024Article
- A brainstem circuit for gravity-guided vertical navigation.bioRxiv : the preprint server for biology · 2024Article
- Vestibular dysfunction and its association with cognitive impairment and dementia.Frontiers in neuroscience · 2024Review
- Angular Head Velocity Cells within Brainstem Nuclei Projecting to the Head Direction Circuit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Article
25 more citing papers are in PubMed but not listed here.
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2 authors.
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Abstract
Accurate navigation depends on a network of neural systems that encode the moment-to-moment changes in an animal's directional orientation and location in space. Within this navigation system are head direction (HD) cells, which fire persistently when an animal's head is pointed in a particular direction (Sharp et al., 2001a; Taube, 2007). HD cells are widely thought to underlie an animal's sense of spatial orientation, and research over the last 25+ years has revealed that this robust spatial signal is widely distributed across subcortical and cortical limbic areas. The purpose of the present review is to summarize some of the recent studies arguing that the origin of the HD signal resides subcortically, specifically within the reciprocal connections of the dorsal tegmental and lateral mammillary nuclei. Furthermore, we review recent work identifying "bursting" cellular activity in the HD cell circuit after lesions of the vestibular system, and relate these observations to the long held view that attractor network mechanisms underlie HD signal generation. Finally, we summarize anatomical and physiological work suggesting that this attractor network architecture may reside within the tegmento-mammillary circuit.
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