ArticleFrontiers in cellular neuroscience2012
Steroid modulation of hippocampal plasticity: switching between cognitive and emotional memories.
Article in Frontiers in cellular neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 59 citations in OpenAlex.
- Discrete and differentiated encoding of distinct components of spatial experience occurs within the proximodistal subfields of the dorsoventral axis of the hippocampus.Frontiers in behavioral neuroscience · 2026Article
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- Characterization of transcriptional profiles associated with stress-induced neuronal activation in Arc-GFP mice.Molecular psychiatry · 2024Article
- Conventional Synthetic Disease-Modifying Anti-Rheumatic Drugs and the Risk of Vascular Dementia in Patients with Spondyloarthritis: A Database Cohort Study.Journal of clinical medicine · 2023Article
- Different Synaptic Plasticity After Physiological and Psychological Stress in the Anterior Insular Cortex in an Observational Fear Mouse Model.Frontiers in synaptic neuroscience · 2022Article
- Generalization of Conditioned Auditory Fear is Regulated by Maternal Effects on Ventral Hippocampal Synaptic Plasticity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Pre-trauma Methylphenidate in rats reduces PTSD-like reactions one month later.Translational psychiatry · 2017Article
- Stress and Corticosteroids Modulate Muscarinic Long Term Potentiation (mLTP) in the Hippocampus.Frontiers in cellular neuroscience · 2017Article
- Patterns of Theta Activity in Limbic Anxiety Circuit Preceding Exploratory Behavior in Approach-Avoidance Conflict.Frontiers in behavioral neuroscience · 2016Article
- Maternal care differentially affects neuronal excitability and synaptic plasticity in the dorsal and ventral hippocampus.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Preferential loss of dorsal-hippocampus synapses underlies memory impairments provoked by short, multimodal stress.Molecular psychiatry · 2014Article
- Stress-related factors in the emergence of transient global amnesia with hippocampal lesions.Frontiers in behavioral neuroscience · 2014Article
- Prolonged systemic inflammation persistently modifies synaptic plasticity in the hippocampus: modulation by the stress hormones.Frontiers in molecular neuroscience · 2013Article
- Stress affects theta activity in limbic networks and impairs novelty-induced exploration and familiarization.Frontiers in behavioral neuroscience · 2013Article
- Stress-induced memory retrieval impairments: different time-course involvement of corticosterone and glucocorticoid receptors in dorsal and ventral hippocampus.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Article
- Stress and steroid regulation of synaptic transmission: from physiology to pathophysiology.Frontiers in cellular neuroscience · 2012Article
- Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several new observations have shifted the view of the hippocampus from a structure in charge of cognitive processes to a brain area that participates in the formation of emotional memories, in addition to its role in cognition. Specifically, while the dorsal hippocampus is involved in the processing of cognitive memories; the ventral sector is mainly associated with the control of behavioral inhibition, stress, and emotional memory. Stress is likely to cause this switch in control of hippocampal functions by modulating synaptic plasticity in the dorsal and ventral sectors of the hippocampus through the differential activation of mineralocorticosteroid or glucocorticosteroid receptors. Herein, we will review the effects of stress hormones on synaptic plasticity in the hippocampus and outline the outcomes on stress-related global functions of this structure. We propose that steroid hormones act as molecular switches: by changing the strength of synaptic connectivity in the hippocampus following stress, they regulate the routes by which the hippocampus is functionally linked to the rest of the brain. This hypothesis has profound implications for the pathophysiology of psychiatric disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.