ArticleThe Journal of infectious diseases2012
Impact of persistent HIV replication on CD4 negative Vγ2Vδ2 T cells.
Article in The Journal of infectious diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 20 citations in OpenAlex.
- γδ T cells mediate robust anti-HIV functions during antiretroviral therapy regardless of immune checkpoint expression.Clinical & translational immunology · 2024Article
- Emerging features of MAIT cells and other unconventional T cell populations in human viral disease and vaccination.Seminars in immunology · 2022Review
- Unbiased Profiling Reveals Compartmentalization of Unconventional T-Cells Within the Intestinal Mucosa Irrespective of HIV Infection.Frontiers in immunology · 2020Article
- Emerging role of γδ T cells in vaccine-mediated protection from infectious diseases.Clinical & translational immunology · 2019Review
- γδ T-cell responses during HIV infection and antiretroviral therapy.Clinical & translational immunology · 2019Review
- Mucosal and Systemic γδ+ T Cells Associated with Control of Simian Immunodeficiency Virus Infection.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Functional dichotomy of Vδ2 γδ T cells in chronic hepatitis C virus infections: role in cytotoxicity but not for IFN-γ production.Scientific reports · 2016Article
- Adoptive transfer of aminobisphonate-expanded Vγ9Vδ2+ T cells does not control HIV replication in a humanized mouse model.Immunotherapy · 2016Article
- Distortion of memory Vδ2 γδ T cells contributes to immune dysfunction in chronic HIV infection.Cellular & molecular immunology · 2015Article
- HIV infection of monocytes-derived dendritic cells inhibits Vγ9Vδ2 T cells functions.PloS one · 2014Article
- γδ T Cells in HIV Disease: Past, Present, and Future.Frontiers in immunology · 2014Review
- Levels of CD56+TIM-3- effector CD8 T cells distinguish HIV natural virus suppressors from patients receiving antiretroviral therapy.PloS one · 2014Article
- The potential role of CD16+ Vγ2Vδ2 T cell-mediated antibody-dependent cell-mediated cytotoxicity in control of HIV type 1 disease.AIDS research and human retroviruses · 2013Article
- Reply to Hartjen et al.The Journal of infectious diseases · 2013Article
- The γδ T-cell receptor repertoire is reconstituted in HIV patients after prolonged antiretroviral therapy.AIDS (London, England) · 2013Article
- Depletion and dysfunction of Vγ2Vδ2 T cells in HIV disease: mechanisms, impacts and therapeutic implications.Cellular & molecular immunology · 2013Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundCD4- Vγ2Vδ2 T cells are depleted during human immunodeficiency virus (HIV) infection but can recover to near normal levels in patients who spontaneously control viremia in the absence of therapy. By contrasting Vγ2Vδ2 T-cell numbers, phenotype, and T-cell receptor (TCR) repertoire, we investigate the dynamic tension between active immunity and progressive T-cell destruction during persistent viremia.
methodsPeripheral blood Vγ2Vδ2 T-cell levels and phenotypes were characterized by flow cytometry. Lymphoproliferation assays measured functional responses. Spectratyping characterized damage to the TCR repertoire.
resultsLevels, responses to antigen and the proportion of T effector memory Vγ2Vδ2 T cells in patients with persistent viremia, were intermediate between patients with natural virus suppression (NVS) and patients receiving antiretroviral therapy. Damage to the TCR γ-2 chain repertoire and depletion of CD56+ Vγ2Vδ2 T cells were more pronounced in viremic patients, compared with antiretroviral therapy recipients and patients with natural virus suppression.
conclusionsCharacteristics of Vγ2Vδ2 T cells in viremic patients reflect both active responses (increasing cell numbers, better antigen responses, and higher proportion of effector memory cells) and ongoing damage (repertoire changes and loss of CD56+ cells). Unlike patients who control viremia to undetectable levels, Vγ2Vδ2 T cells are diminished during persistent viremia and may eventually be lost because of progressive destruction of the TCR repertoire.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.