ArticleEndocrine-related cancer2012
Genetic characterization of large parathyroid adenomas.
Article in Endocrine-related cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Giant parathyroid tumours in primary hyperparathyroidism: a systematic review.Langenbeck's archives of surgery · 2022Pooled it
- Current Knowledge on Atypical Parathyroid Tumors and Emerging Strategies for Risk Stratification.Endocrinology and metabolism (Seoul, Korea) · 2026Review
- A Comparative Genomic Analysis of Parathyroid Adenomas and Carcinomas Harboring Heterozygous Germline CDC73 Mutations.The Journal of clinical endocrinology and metabolism · 2025Article
- Syndromic MEN1 parathyroid adenomas consist of both subclonal nodules and clonally independent tumors.Virchows Archiv : an international journal of pathology · 2024Article
- Clinical and genetic analysis of atypical parathyroid adenoma compared with parathyroid carcinoma and benign lesions in a Chinese cohort.Frontiers in endocrinology · 2023Article
- Giant Parathyroid Adenoma: A Case Report.Cureus · 2023Article
- Giant parathyroid adenoma and challenges with preoperative differentiation from malignancy.BMJ case reports · 2021Article
- A Rare Case of Primary Hyperparathyroidism Caused by a Giant Solitary Parathyroid Adenoma.The American journal of case reports · 2018Review
- Inflammatory infiltrates in parathyroid tumors.European journal of endocrinology · 2017Article
- Giant mediastinal parathyroid adenoma presenting as bilateral brown tumour of mandible: a rare presentation of primary hyperparathyroidism.BMJ case reports · 2017Article
- An Excess of CYP24A1, Lack of CaSR, and a Novel lncRNA Near the PTH Gene Characterize an Ectopic PTH-Producing Tumor.Journal of the Endocrine Society · 2017Article
- Mutational Analysis ofJournal of the Endocrine Society · 2017Article
- Article
- Acute presentation of a giant intrathyroidal parathyroid adenoma: a case report.Journal of medical case reports · 2016Article
- Molecular Characteristics of Large Parathyroid Adenomas.World journal of surgery · 2016Article
- Article
- Radiological considerations and surgical planning in the treatment of giant parathyroid adenomas.Annals of the Royal College of Surgeons of England · 2015Article
- MicroRNA deregulation in parathyroid tumours suggests an embryonic signature.Journal of endocrinological investigation · 2015Review
- Tumour nuclear oestrogen receptor beta 1 correlates inversely with parathyroid tumour weight.Endocrine connections · 2015Article
- Differential protein expression profiles of cyst fluid from papillary thyroid carcinoma and benign thyroid lesions.PloS one · 2015Article
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7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, we genetically characterized parathyroid adenomas with large glandular weights, for which independent observations suggest pronounced clinical manifestations. Large parathyroid adenomas (LPTAs) were defined as the 5% largest sporadic parathyroid adenomas identified among the 590 cases operated in our institution during 2005-2009. The LPTA group showed a higher relative number of male cases and significantly higher levels of total plasma and ionized serum calcium (P<0.001). Further analysis of 21 LPTAs revealed low MIB1 proliferation index (0.1-1.5%), MEN1 mutations in five cases, and one HRPT2 (CDC73) mutation. Total or partial loss of parafibromin expression was observed in ten tumors, two of which also showed loss of APC expression. Using array CGH, we demonstrated recurrent copy number alterations most frequently involving loss in 1p (29%), gain in 5 (38%), and loss in 11q (33%). Totally, 21 minimal overlapping regions were defined for losses in 1p, 7q, 9p, 11, and 15q and gains in 3q, 5, 7p, 8p, 16q, 17p, and 19q. In addition, 12 tumors showed gross alterations of entire or almost entire chromosomes most frequently gain of 5 and loss of chromosome 11. While gain of 5 was the most frequent alteration observed in LPTAs, it was only detected in a small proportion (4/58 cases, 7%) of parathyroid adenomas. A significant positive correlation was observed between parathyroid hormone level and total copy number gain (r=0.48, P=0.031). These results support that LPTAs represent a group of patients with pronounced parathyroid hyperfunction and associated with specific genomic features.
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