ArticleEuropean archives of psychiatry and clinical neuroscience2012
Dissociable morphometric differences of the inferior parietal lobule in schizophrenia.
Article in European archives of psychiatry and clinical neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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26 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Striato-limbic and frontoparietal dysfunction underlying imbalance of reward-motivation and cognitive control in compulsive sexual behaviour disorder: A neuroimaging meta-analysis.Journal of behavioral addictions · 2026Pooled it
- Altered Cortical Gyrification Is Associated with Cortical and White Matter Microstructure in Individuals with Early Psychosis: A Multimodal Neuroimaging Study.Schizophrenia bulletin · 2026Article
- Altered cortical gyrification as a marker of treatment resistance in patients with first-episode psychosis.Translational psychiatry · 2025Article
- Network analysis of relationships among psychopathology, cognitive function, and psychosocial functioning in independent samples of Chinese with schizophrenia or bipolar disorder.Psychological medicine · 2025Article
- Sensory and Multisensory Processing Changes and Their Contributions to Autism and Schizophrenia.Current topics in behavioral neurosciences · 2025Review
- Effects of long-term antipsychotic medication on brain instability in first-episode schizophrenia patients: a resting-state fMRI study.Frontiers in pharmacology · 2024Article
- Association of clozapine with structural and resting-state functional abnormalities of the hippocampus in chronic schizophrenia.Frontiers in psychiatry · 2024Article
- Association of dopamine-based genetic risk score with dynamic low-frequency fluctuations in first-episode drug-naïve schizophrenia.Brain imaging and behavior · 2023Article
- Degeneracy and disordered brain networks in psychiatric patients using multivariate structural covariance analyzes.Frontiers in psychiatry · 2023Article
- Reduced cortical gyrification in the posteromedial cortex in unaffected relatives of schizophrenia patients with high genetic loading.NPJ schizophrenia · 2021Article
- Cognitive Profiles and Functional Connectivity in First-Episode Schizophrenia Spectrum Disorders - Linking Behavioral and Neuronal Data.Frontiers in psychology · 2019Article
- Network-based decoupling of local gyrification in obsessive-compulsive disorder.Human brain mapping · 2018Article
- Cortical gyrification in schizophrenia: current perspectives.Neuropsychiatric disease and treatment · 2018Review
- Polygenic Risk for Schizophrenia Influences Cortical Gyrification in 2 Independent General Populations.Schizophrenia bulletin · 2017Article
- Gyri of the human parietal lobe: Volumes, spatial extents, automatic labelling, and probabilistic atlases.PloS one · 2017Article
- Increased diffusivity in gray matter in recent onset schizophrenia is associated with clinical symptoms and social cognition.Schizophrenia research · 2016Article
- Selective functional connectivity abnormality of the transition zone of the inferior parietal lobule in schizophrenia.NeuroImage. Clinical · 2016Article
- Task-independent effects are potential confounders in longitudinal imaging studies of learning in schizophrenia.NeuroImage. Clinical · 2016Article
- Structural correlates of formal thought disorder in schizophrenia: An ultra-high field multivariate morphometry study.Schizophrenia research · 2015Article
- Magnetic resonance imaging and the prediction of outcome in first-episode schizophrenia: a review of current evidence and directions for future research.Schizophrenia bulletin · 2015Review
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2 authors at 1 institution in 1 country.
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Abstract
Inferior parietal lobule (IPL) forms an integral part of a critical frontoparietal network, which has been implicated in various clinical symptoms and cognitive deficits seen in schizophrenia. Despite its functional relevance, the relatively few studies that have investigated the structural changes in the IPL report inconsistent findings concerning the nature and localization of these changes. We employed a blinded, automated labelling procedure to measure cortical thickness, surface area and the degree of cortical folding of the two distinct subregions of the IPL (Angular Gyrus and Supramarginal Gyrus) in 57 patients with schizophrenia and 41 controls using high-resolution magnetic resonance imaging. Within the IPL, we observed more pronounced morphological changes in supramarginal gyrus compared to angular gyrus in schizophrenia. While supramarginal gyrus in patients showed reduced gyrification, contracted surface area and thinning, the morphometric changes in angular gyrus were largely confined to a reduction in surface area. Significant hemispheric asymmetry was observed in the gyrification of the supramarginal gyrus. Our findings suggest that in addition to abnormalities in the neurodevelopmental processes that contribute to regional surface area and cortical thickness, a specific defect in cortical folding, especially affecting the left hemisphere, is likely to occur in schizophrenia.
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