Evidence map›Paper›PMID 22454239›Full record

ReviewHormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme2012

Convergence of multiple mechanisms of steroid hormone action.

S K Mani, P G Mermelstein, M J Tetel, G Anesetti

Abstract readReview
In one paragraph

Review in Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 56 citations in OpenAlex.

  1. Article
  2. Sex Differences in the Lacrimal Gland: Implications for Dry Eye Disease.International journal of molecular sciences · 2025
    Review
  3. Expression of Androgen and Estrogen Receptors in the Human Lacrimal Gland.International journal of molecular sciences · 2023
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Hormonal Influences on Cognitive Function.The Malaysian journal of medical sciences : MJMS · 2018
    Review
  9. Review
  10. Review
  11. Actions of Steroids: New Neurotransmitters.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016
    Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Review
  18. Advances in neuroendocrine mechanisms.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2012
    Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 2 countries.

S K ManiDepartment of Molecular & Cellular Biology and Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA. smani@bcm.tmc.edu
P G Mermelstein
M J Tetel
G Anesetti
Baylor College of Medicine · USUniversidad de la República · UYUniversity of Minnesota · USWellesley College · US

Funding

Mechanisms of Steroid Hormone Action in BrainR01DK061935 · NIDDK · WELLESLEY COLLEGE · PI TETEL, MARC JEFFREY · 2002 to 2014
$2.7M
Novel Actions of Estradiol that Influence Brain FunctionR01NS041302 · NINDS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI MERMELSTEIN, PAUL G · 2001 to 2010
$2.5M
Non-Classical Cellular Pathways for Progesterone Regulation of BehaviorR01HD062512 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI MANI, SHAILAJA K · 2010 to 2014
$1.6M
NICHD NIH HHS HD062512NICHD NIH HHS R01 HD062512NIDDK NIH HHS R01 DK061935NIDDK NIH HHS R01 DK61935NINDS NIH HHS NS 041302NINDS NIH HHS NS 062125NINDS NIH HHS R01 NS041302
6 · The paper itself

Abstract

Steroid hormones modulate a wide array of physiological processes including development, metabolism, and reproduction in various species. It is generally believed that these biological effects are predominantly mediated by their binding to specific intracellular receptors resulting in conformational change, dimerization, and recruitment of coregulators for transcription-dependent genomic actions (classical mechanism). In addition, to their cognate ligands, intracellular steroid receptors can also be activated in a "ligand-independent" manner by other factors including neurotransmitters. Recent studies indicate that rapid, nonclassical steroid effects involve extranuclear steroid receptors located at the membrane, which interact with cytoplasmic kinase signaling molecules and G-proteins. The current review deals with various mechanisms that function together in an integrated manner to promote hormone-dependent actions on the central and sympathetic nervous systems.

Indexed as

AnimalsBehaviorBrainEstrogensHumansProgesteroneReceptors, SteroidSignal TransductionEstrogensProgesteroneReceptors, Steroid

Identifiers

PMID22454239
PMCPMC3646380
OpenAlexW2146953408

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.