ArticleLasers in medical science2013
Topical photodynamic treatment with poly-L-lysine-chlorin p6 conjugate improves wound healing by reducing hyperinflammatory response in Pseudomonas aeruginosa-infected wounds of mice.
Article in Lasers in medical science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Antimicrobial photodynamic therapy in skin wound healing: A systematic review of animal studies.International wound journal · 2020Pooled it
- Lactobacillus acidophilus-Derived Cell-Free Supernatant Augments Methylene Blue-Mediated Photodynamic Inactivation Efficacy Against Methicillin Resistant Staphylococcus aureus Planktonic Suspension and Biofilms.Probiotics and antimicrobial proteins · 2026Article
- Analysis of Self-Assembled Low- and High-Molecular-Weight Poly-L-Lysine-Ce6 Conjugate-Based Nanoparticles.Biomolecules · 2024Article
- Photodynamic Therapy, Probiotics, Acetic Acid, and Essential Oil in the Treatment of Chronic Wounds Infected withPharmaceutics · 2023Review
- Photodynamic disinfection and its role in controlling infectious diseases.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2021Review
- Antibacterial photodynamic activity of photosensitizer-embedded alginate-pectin-carboxymethyl cellulose composite biopolymer films.Lasers in medical science · 2021Article
- The Role of Porphyrinoid Photosensitizers for Skin Wound Healing.International journal of molecular sciences · 2021Review
- Design of Photosensitizing Agents for Targeted Antimicrobial Photodynamic Therapy.Molecules (Basel, Switzerland) · 2020Review
- Photodynamic antimicrobial chemotherapy in mice with Pseudomonas aeruginosa-infected wounds.PloS one · 2020Article
- Construction of injectable, pH sensitive, antibacterial, mineralized amino acid yolk-shell microspheres for potential minimally invasive treatment of bone infection.International journal of nanomedicine · 2018Article
- Nanomedicine and advanced technologies for burns: Preventing infection and facilitating wound healing.Advanced drug delivery reviews · 2018Review
- Photoinactivation effect of eosin methylene blue and chlorophyllin sodium-copper against Staphylococcus aureus and Escherichia coli.Lasers in medical science · 2017Article
- Photoantimicrobials-are we afraid of the light?The Lancet. Infectious diseases · 2017Review
- Photodynamic antimicrobial chemotherapy with the novel amino acid-porphyrin conjugate 4I: In vitro and in vivo studies.PloS one · 2017Article
- Histological Evaluation of Wound Healing Process after Photodynamic Therapy of Rat Oral Mucosal Ulcer.Journal of dentistry (Shiraz, Iran) · 2016Article
- Antibacterial photodynamic therapy: overview of a promising approach to fight antibiotic-resistant bacterial infections.Journal of clinical and translational research · 2015Review
- Modulation of inflammatory response of wounds by antimicrobial photodynamic therapy.Laser therapy · 2015Article
- Topical antimicrobial photodynamic therapy improves angiogenesis in wounds of diabetic mice.Lasers in medical science · 2015Article
- Synthesis and Characterization of L-Lysine Conjugated Silver Nanoparticles Smaller Than 10 nM.Advanced science, engineering and medicine · 2014Article
- Evaluation of antibacterial photodynamic efficacy of a novel cationic near infrared chlorophyll derivative against planktonic and biofilm-borne methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa.Photochemistry and photobiologyArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report the results of our investigations on the effect of antimicrobial photodynamic treatment (APDT) with poly-lysine-conjugated chlorin p6 (pl-cp6) on proinflammatory cytokine expression and wound healing in a murine excisional wound model infected with Pseudomonas aeruginosa. Treatment of infected wounds with pl-cp6 and light doses of 60 and 120 J/cm(2) reduced the bacterial load by ~1.5 and 2.0 log, respectively, after 24 h. The treated wounds healed ~5 days earlier as compared to untreated control and wound closure was not dependent on light dose. Interestingly, at 96 h post-treatment, drug-treated wounds irradiated at 60 J/cm(2) showed considerable reduction of proinflammatory cytokines IL-6 (approximately five times) and TNF-α (approximately four times) compared to untreated control. Further, exposure of culture supernatants to similar light dose and pl-cp6 concentration under in vitro conditions reduced the protease activity by ~50 % as compared to the untreated control, suggesting inactivation of extracellular virulent factors. Additionally, histological analysis of treated infected wounds showed complete reepithelialization, ordered collagen fibers, and considerable decrease in inflammatory cell infiltration compared to untreated wounds. These results imply that pl-cp6-mediated PDT reduces hyperinflammatory response of infected wounds, leading to acceleration of wound healing.
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