ArticleInternational journal of colorectal disease2012
Additional colectomy after colonoscopic polypectomy for T1 colon cancer: a fine balance between oncologic benefit and operative risk.
Article in International journal of colorectal disease, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02328664 (The Sensitivity of Scar-biopsies for Residual Colorectal Adenocarcinoma After Endoscopic Resection With Uncertain Radicality), which is not on this map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Sensitivity of Scar-biopsies for Residual Colorectal Adenocarcinoma After Endoscopic Resection With Uncertain Radicality
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Risk assessment of lymph node metastasis and comparison of treatment modalities for low-risk T1b colorectal cancer: a meta-analysis.Surgical endoscopy · 2025Pooled it
- Colon cancer: the 2023 Korean clinical practice guidelines for diagnosis and treatment.Annals of coloproctology · 2024Guideline
- Does Local Excision Without Salvage Surgery Affect the Prognostic Outcome of Patients With Malignant Colorectal Polyp? A Long-Term Survival Analysis.Journal of gastroenterology and hepatology · 2026Article
- Rethinking surgical strategy for margin-positive only T1 colorectal cancer: a multicenter retrospective cohort study.International journal of colorectal disease · 2026Article
- Expanded Indications in Advanced Endoscopic Resection of Malignant Gastrointestinal Lesions.Current gastroenterology reports · 2026Review
- Predictors of early colorectal cancer metastasis to lymph nodes: providing rationale for therapy decisions.Frontiers in oncology · 2024Review
- Impact of ≥ 0.1-mm free resection margins on local intramural residual cancer after local excision of T1 colorectal cancer.Endoscopy international open · 2022Article
- High practice variation in risk stratification, baseline oncological staging, and follow-up strategies for T1 colorectal cancers in the Netherlands.Endoscopy international open · 2020Article
- Early stage colon cancer: Current treatment standards, evolving paradigms, and future directions.World journal of gastrointestinal oncology · 2020Review
- Long-Term Outcomes of T1 Colorectal Cancer after Endoscopic Resection.Journal of clinical medicine · 2020Article
- National cohort study on postoperative risks after surgery for submucosal invasive colorectal cancer.BJS open · 2019Observational
- Malignant colorectal polyps: endoscopic polypectomy and watchful waiting is not inferior to subsequent bowel resection. A nationwide propensity score-based analysis.Langenbeck's archives of surgery · 2019Article
- Endoscopic Submucosal Dissection Decreases Additional Colorectal Resection for T1 Colorectal Cancer.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Expression of matrix metalloproteinase-7 correlates with the invasion of T1 colorectal carcinoma.Oncology letters · 2018Article
- Management of complex polyps of the colon and rectum.International journal of colorectal disease · 2018Review
- Increased Rate of Incidental Colorectal Malignant Polyps: A Single-Center Experience.Surgery research and practice · 2018Article
- Practical problems of measuring depth of submucosal invasion in T1 colorectal carcinomas.International journal of colorectal disease · 2016Article
- A clinical model for predicting lymph node metastasis in submucosal invasive (T1) colorectal cancer.International journal of colorectal disease · 2015Article
- Novel risk factors for lymph node metastasis in early invasive colorectal cancer: a multi-institution pathology review.Journal of gastroenterology · 2014Article
- Additional Surgical Resection After Endoscopic Resection for Patients With High-risk T1 Colorectal Cancer.In vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe treatment of early-stage colorectal cancers removed endoscopically depends on histopathologic findings. This study aimed to assess the benefit-risk balance for patients who underwent additional surgery after endoscopic resection of a T1 carcinoma with unfavorable histology.
methodsFrom 2000 to 2010, 64 consecutive patients were included in this retrospective study. Specimens resected after endoscopic polypectomy showed at least one of the following unfavorable factors: no free margin, lymphovascular invasion, poorly differentiated grade, SM2-3 involvement (submucosal invasion greater than 300 μm from the muscularis mucosae), tumor budding, sessile morphology, and piecemeal resection. The main objective was to assess the benefit-risk balance of an oncological resection performed after the polypectomy. Oncological benefit was measured by the lymph node metastasis rate and the persistence of a residual adenocarcinoma on the specimen. The risk was measured by the occurrence of severe complications of grade III-IV or death. The associations between these end points and clinicopathologic variables were evaluated by univariate analysis and logistic regression.
resultsFive patients (7.8 %) had lymph node metastases and two (3.1 %) had residual carcinomas. Eight patients (12.5 %) had grade III-IV morbidity. There were no deaths. Oncological benefit was associated by logistic regression analysis with patients who presented multiple criteria (≥2) that led to surgery (p = 0.031). The benefit-risk balance was favorable only for those patients.
conclusionsAdditional surgery is required for patients who present multiple adverse histological criteria. If only one criterion is selected, the indication should be discussed, especially for patients with multiple comorbidities.
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