ArticleJournal of computational neuroscience2012
A mathematical model for astrocytes mediated LTP at single hippocampal synapses.
Article in Journal of computational neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Analysis of Network Models with Neuron-Astrocyte Interactions.Neuroinformatics · 2023Article
- Article
- Neuron-Glia Interactions and Brain Circuits.Advances in experimental medicine and biology · 2022Article
- Unraveling Aβ-Mediated Multi-Pathway Calcium Dynamics in Astrocytes: Implications for Alzheimer's Disease Treatment From Simulations.Frontiers in physiology · 2021Article
- Astrocyte as Spatiotemporal Integrating Detector of Neuronal Activity.Frontiers in physiology · 2019Article
- Article
- Computational Models for Calcium-Mediated Astrocyte Functions.Frontiers in computational neuroscience · 2018Review
- Astrocytes Modulate Local Field Potential Rhythm.Frontiers in integrative neuroscience · 2015Article
- Mechanisms of heterosynaptic metaplasticity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- A possible role of astrocytes in contextual memory retrieval: An analysis obtained using a quantitative framework.Frontiers in computational neuroscience · 2013Article
- A mathematical model of the tripartite synapse: astrocyte-induced synaptic plasticity.Journal of biological physics · 2012Article
- Assessing the Effects of Opioids on Pathological Memory by a Computational Model.Basic and clinical neuroscienceArticle
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many contemporary studies have shown that astrocytes play a significant role in modulating both short and long form of synaptic plasticity. There are very few experimental models which elucidate the role of astrocyte over Long-term Potentiation (LTP). Recently, Perea and Araque (Science 317:1083-1086, 2007) demonstrated a role of astrocytes in induction of LTP at single hippocampal synapses. They suggested a purely pre-synaptic basis for induction of this N-methyl-D-Aspartate (NMDA) Receptor-independent LTP. Also, the mechanisms underlying this pre-synaptic induction were not investigated. Here, in this article, we propose a mathematical model for astrocyte modulated LTP which successfully imitates the experimental findings of Perea and Araque (Science 317:1083-1086, 2007). Our study suggests the role of retrograde messengers, possibly Nitric Oxide (NO), for this pre-synaptically modulated LTP.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.