Evidence map›Paper›PMID 22453981›Full record

ReviewAdvances in experimental medicine and biology2012

Mechanosensory calcium signaling.

Thomas J Jones, Surya M Nauli

Abstract readReview
In one paragraph

Review in Advances in experimental medicine and biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Flow stimulated endocytosis in the proximal tubule.Current opinion in nephrology and hypertension · 2015
    Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Thomas J JonesDepartment of Pharmacology, The University of Toledo, Health Science Campus; HEB 274, 3000 Arlington Ave. MS 1015, Toledo, OH 43614, USA.
Surya M Nauli

Funding

The roles of primary cilia in cardiovascular systemR01DK080640 · NIDDK · UNIVERSITY OF TOLEDO · PI NAULI, SURYA · 2008 to 2012
$1.6M
Mechanosensory role endothelial cilia polycystic kidneyR21HL084451 · NHLBI · UNIVERSITY OF TOLEDO · PI NAULI, SURYA · 2006 to 2007
$388k
NHLBI NIH HHS R21 HL084451NIDDK NIH HHS DK080640NIDDK NIH HHS R01 DK080640
6 · The paper itself

Abstract

Mechanotransduction describes the cellular process by which mechanical stimuli are translated into intracellular adaptive responses through biochemical signals. Current research has begun to focus on the once-forgotten organelle, the primary cilia, in this mechanotransduction process. Primary cilia are found on almost every cell type, with a functional role in transducing mechanical and extracellular signals towards intracellular responses through the ciliary extension into the extracellular space. In this regard, the modulation of intracellular calcium signaling by various mechanical stimuli has generated an assortment of attractive models to understand this mechanotransduction process.

Indexed as

AnimalsCalcium SignalingCell MovementCytoskeletonHumansMechanotransduction, Cellular

Identifiers

PMID22453981
PMCPMC11957381

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.