ReviewAdvances in experimental medicine and biology2012
Ca(2+) signaling: an outlook on the characterization of Ca(2+) channels and their importance in cellular functions.
Review in Advances in experimental medicine and biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- Calcium dysregulation in neurovascular function in Alzheimer's disease: mechanisms, therapeutic targets.GeroScience · 2026Review
- Huoxue Qianyang Qutan Recipe limits cardiac remodeling by regulating FUNDC1/IP3R2 signaling pathway in obese hypertensive rats.Scientific reports · 2026Article
- Mitochondrial CaInternational journal of molecular sciences · 2022Review
- Differential activation of CaNPJ Regenerative medicine · 2021Article
- Oxidative Stress, Mitochondrial Dysfunction, and Neuroprotection of Polyphenols with Respect to Resveratrol in Parkinson's Disease.Biomedicines · 2021Review
- Activation of Cx43 Hemichannels Induces the Generation of CaInternational journal of molecular sciences · 2021Article
- Calcium channels and their role in regenerative medicine.World journal of stem cells · 2021Review
- Molecular nature and physiological role of the mitochondrial calcium uniporter channel.American journal of physiology. Cell physiology · 2021Review
- Advances in CaExperimental and therapeutic medicine · 2020Review
- Review
- Macrophage TLR4 and PAR2 Signaling: Role in Regulating Vascular Inflammatory Injury and Repair.Frontiers in immunology · 2020Review
- Effects of Cr(VI) exposure on electrocardiogram, myocardial enzyme parameters, inflammatory factors, oxidative kinase, and ATPase of the heart in Chinese rural dogs.Environmental science and pollution research international · 2019Article
- Article
- The Blockade of Store-Operated Calcium Channels Improves Decompression Sickness in Rats.Frontiers in physiology · 2019Article
- Into the breach: how cells cope with wounds.Open biology · 2018Review
- High salt induces P-glycoprotein mediated treatment resistance in breast cancer cells through store operated calcium influx.Oncotarget · 2018Article
- New Insights in Cardiac Calcium Handling and Excitation-Contraction Coupling.Advances in experimental medicine and biology · 2018Review
- Hydrogen gas protects IP3Rs by reducing disulfide bridges in human keratinocytes under oxidative stress.Scientific reports · 2017Article
- A novel mechanism underlies atrazine toxicity in quails (Coturnix Coturnix coturnix): triggering ionic disorder via disruption of ATPases.Oncotarget · 2016Article
- Protection of the cochlear hair cells in adult C57BL/6J mice by T-type calcium channel blockers.Experimental and therapeutic medicine · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Calcium (Ca(2+)) is essential in regulating a plethora of cellular functions that includes cell proliferation and differentiation, axonal guidance and cell migration, neuro/enzyme secretion and exocytosis, development/maintenance of neural circuits, cell death and many more. Since Ca(2+) regulates so many fundamental processes, it could be anticipated that numerous Ca(2+) channels and transporters will assist in regulating Ca(2+) entry across the plasma membrane. Towards this several Ca(2+) channels such as voltage-gated channels, store-operated Ca(2+) entry (SOCE) channels, NMDA, AMPA and other ligand gated channels have been identified. In recent years research focus has been targeted towards identification of the precise function of these essential channels. Furthermore, characterization of these individual Ca(2+) channels has also gained much attention, since specific Ca(2+) channels have been shown to influence a particular cellular response. Moreover, perturbations in these Ca(2+) channels have also been implicated in a spectrum of pathological conditions. Hence, understanding the precise involvement of these Ca(2+) channels in disease conditions would presumably unveil avenues for plausible therapeutic interventions. We thus review the role of Ca(2+) signaling in select -disease conditions and also provide experimental evidence as how they can be characterized in a given cell.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.