ArticlePediatric radiology2012
The correlation between DTI parameters and levels of AQP-4 in the early phases of cerebral edema after hypoxic-ischemic/reperfusion injury in piglets.
Article in Pediatric radiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Hypoxic-ischemic-related cerebrovascular changes and potential therapeutic strategies in the neonatal brain.Journal of neuroscience research · 2020Review
- Vasogenic cerebral edema associated with the disability in activities of daily living in patients with chronic obstructive pulmonary disease.Brain and behavior · 2018Article
- Protective effects of nicorandil against cerebral injury in a swine cardiac arrest model.Experimental and therapeutic medicine · 2018Article
- The Applicability of Amide Proton Transfer Imaging in the Nervous System: Focus on Hypoxic-Ischemic Encephalopathy in the Neonate.Cellular and molecular neurobiology · 2018Review
- Expression Changes in Lactate and Glucose Metabolism and Associated Transporters in Basal Ganglia following Hypoxic-Ischemic Reperfusion Injury in Piglets.AJNR. American journal of neuroradiology · 2018Article
- Comparison between ultra-high and conventional mono b-value DWI for preoperative glioma grading.Oncotarget · 2017Article
- Measurement of Lactate Content and Amide Proton Transfer Values in the Basal Ganglia of a Neonatal Piglet Hypoxic-Ischemic Brain Injury Model Using MRI.AJNR. American journal of neuroradiology · 2017Article
- Melatonin alleviates brain and peripheral tissue edema in a neonatal rat model of hypoxic-ischemic brain damage: the involvement of edema related proteins.BMC pediatrics · 2017Article
- Early Changes in Glutamate Metabolism and Perfusion in Basal Ganglia following Hypoxia-Ischemia in Neonatal Piglets: A Multi-Sequence 3.0T MR Study.Frontiers in physiology · 2017Article
- Dynamic regulation of aquaporin-4 water channels in neurological disorders.Croatian medical journal · 2015Review
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundBrain edema during the early stages of hypoxic-ischemic/reperfusion (HI/R) injury can be determined using diffusion tensor imaging (DTI). The change in ADC values has been correlated with the change in expression of AQP-4.
objectiveTo determine cerebral edema at specific time intervals after HI/R injury using DTI modalities and discuss its relationship to the expression of aquaporin-4 (AQP-4). MATERIALS AND
methodsThirty newborn piglets were divided into six groups (2, 6, 12, 24, 48 and 72 h) after HI/R injury. The control group subjected to sham surgery included five piglets. DTI scans and immunohistochemistry of AQP-4 expression were performed on piglet brain. The relationship between DTI parameters (FA and ADC values) and the optical density (OD) of AQP-4 expression was determined.
resultsIn the striatum, ADC values dropped and reached their lowest level at 24 h (F = 27.42, P < 0.05). In the subcortical border region, ADC values increased after a transient decrease and peaked at 48 h, demonstrating a significant difference from the control group (F = 50.25, P < 0.05). FA values in the internal capsules and subcortical white matter in HI/R models decreased continuously after HI/R, although no statistically significant difference from the control group was achieved. ADC and OD values of AQP-4 expression were positively correlated (r = 0.875, P < 0.05).
conclusionsThe change in ADC value after HI/R injury correlates with the expression of AQP-4.
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