Evidence map›Paper›PMID 22453836›Full record

ArticleNature communications2012

Graphene-based wireless bacteria detection on tooth enamel.

Manu S Mannoor, Hu Tao, Jefferson D Clayton, Amartya Sengupta, David L Kaplan, Rajesh R Naik, Naveen Verma, Fiorenzo G Omenetto, Michael C McAlpine

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in Nature communications, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 203 papers.

0numbers the graph read from it
0cells of the map it votes in
203citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

203 citing papers in PubMed.

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  7. Autonomous Polymer Frameworks for Sustainable Tissue-Interfaced Plastic Bioelectronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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  12. Article
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  16. Advances in 2D materials for wearable biomonitoring.Materials science & engineering. R, Reports : a review journal · 2025
    Article
  17. Review
  18. Article
  19. Article
  20. Review

143 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

9 authors.

Manu S MannoorDepartment of Mechanical and Aerospace Engineering, Princeton University, Princeton, New Jersey 08544, USA.
Hu Tao
Jefferson D Clayton
Amartya Sengupta
David L Kaplan
Rajesh R Naik
Naveen Verma
Fiorenzo G Omenetto
Michael C McAlpine

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Direct interfacing of nanosensors onto biomaterials could impact health quality monitoring and adaptive threat detection. Graphene is capable of highly sensitive analyte detection due to its nanoscale nature. Here we show that graphene can be printed onto water-soluble silk. This in turn permits intimate biotransfer of graphene nanosensors onto biomaterials, including tooth enamel. The result is a fully biointerfaced sensing platform, which can be tuned to detect target analytes. For example, via self-assembly of antimicrobial peptides onto graphene, we show bioselective detection of bacteria at single-cell levels. Incorporation of a resonant coil eliminates the need for onboard power and external connections. Combining these elements yields two-tiered interfacing of peptide-graphene nanosensors with biomaterials. In particular, we demonstrate integration onto a tooth for remote monitoring of respiration and bacteria detection in saliva. Overall, this strategy of interfacing graphene nanosensors with biomaterials represents a versatile approach for ubiquitous detection of biochemical targets.

Indexed as

Biosensing TechniquesAntimicrobial Cationic PeptidesBiocompatible MaterialsDental EnamelEscherichia coliGraphiteHelicobacter pyloriHumansNanostructuresNanotechnologySalivaStaphylococcus aureusToothAntimicrobial Cationic PeptidesBiocompatible MaterialsGraphite

Identifiers

PMID22453836

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.