ArticlePrimary care respiratory journal : journal of the General Practice Airways Group2012
Relationship of obesity with respiratory symptoms and decreased functional capacity in adults without established COPD.
Article in Primary care respiratory journal : journal of the General Practice Airways Group, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 37 citations in OpenAlex.
- Bronchodilators for hyperinflation in COPD associated with biomass smoke: clinical trial.International journal of chronic obstructive pulmonary disease · 2019Trial
- Lung function parameters in overweight patients with COPD in relation to body mass index and waist circumference and impact on quality of life.The Journal of international medical research · 2024Article
- Postural orthostatic tachycardia syndrome: A respiratory disorder?Current research in physiology · 2021Review
- Type of Disaster Exposure Affects Functional Limitations of Older People 6 Years Later.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Predictors of prolongation in recent-onset cough.ERJ open research · 2019Article
- Associations between vitamin D, adiposity, and respiratory symptoms in chronic spinal cord injury.The journal of spinal cord medicine · 2018Article
- Functional Limitations Among Responders to the World Trade Center Attacks 14 Years After the Disaster: Implications of Chronic Posttraumatic Stress Disorder.Journal of traumatic stress · 2017Article
- Gender and asthma-chronic obstructive pulmonary disease overlap syndrome.The Journal of asthma : official journal of the Association for the Care of Asthma · 2016Article
- Body mass index, respiratory conditions, asthma, and chronic obstructive pulmonary disease.Respiratory medicine · 2015Article
- Obesity and extent of emphysema depicted at CT.Clinical radiology · 2015Article
- Overweight children report qualitatively distinct asthma symptoms: analysis of validated symptom measures.The Journal of allergy and clinical immunology · 2015Article
- Article
- Obesity, airflow limitation, and respiratory symptoms: does it take three to tango?Primary care respiratory journal : journal of the General Practice Airways Group · 2012Article
- Adiposity increases weight-bearing exercise-induced dyspnea despite favoring resting lung hyperinflation in COPD.Chronic respiratory diseaseArticle
Corrections and comments
- Commented on by
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundObesity contributes to respiratory symptoms and exercise limitation, but the relationships between obesity, airflow obstruction (AO), respiratory symptoms and functional limitation are complex.
aimsTo determine the relationship of obesity with airflow obstruction (AO) and respiratory symptoms in adults without a previous diagnosis of chronic obstructive pulmonary disease (COPD).
methodsWe analysed data for potential referents recruited to be healthy controls for an ongoing study of COPD. The potential referents had no prior diagnosis of COPD or healthcare utilisation attributed to COPD in the 12 months prior to recruitment. Subjects completed a structured interview and a clinical assessment including body mass index, spirometry, six-minute walk test (SMWT), and the Short Performance Physical Battery (SPPB). Multiple regression analyses were used to test the associations of obesity (body mass index >30 kg/m2) and smoking with AO (forced expiratory volume in 1s/forced vital capacity ratio <0.7). We also tested the association of obesity with respiratory symptoms and impaired functional capacity (SPPB, SMWT), adjusting for AO.
resultsOf 371 subjects (aged 40-65 years), 69 (19%) had AO. In multivariate analysis, smoking was positively associated with AO (per 10 pack-years, OR 1.24; 95% CI 1.04 to 1.49) while obesity was negatively associated with AO (OR 0.54; 95% CI 0.30 to 0.98). Obesity was associated with increased odds of reporting dyspnoea on exertion (OR 3.6; 95% CI 2.0 to 6.4), productive cough (OR 2.5; 95% CI 1.1 to 6.0), and with decrements in SMWT distance (67 ± 9 m; 95% CI 50 to 84 m) and SPPB score (OR 1.9; 95% CI 1.1 to 3.5). None of these outcomes was associated with AO.
conclusionsAlthough AO and obesity are both common among adults without an established COPD diagnosis, obesity (but not AO) is linked to a higher risk of reporting dyspnoea on exertion, productive cough, and poorer functional capacity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.