ArticleOptics express2012
Comparative intrinsic optical signal imaging of wild-type and mutant mouse retinas.
Article in Optics express, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Gap junctions fine-tune ganglion cell signals to equalize response kinetics within a given electrically coupled array.iScience · 2024Article
- Intrinsic signal optoretinography of dark adaptation abnormality due to rod photoreceptor degeneration.Experimental biology and medicine (Maywood, N.J.) · 2024Article
- Functional Optical Coherence Tomography for Intrinsic Signal Optoretinography: Recent Developments and Deployment Challenges.Frontiers in medicine · 2022Review
- Functional intrinsic optical signal imaging for objective optoretinography of human photoreceptors.Experimental biology and medicine (Maywood, N.J.) · 2021Article
- Comparative study of wild-type and rd10 mice reveals transient intrinsic optical signal response before phosphodiesterase activation in retinal photoreceptors.Experimental biology and medicine (Maywood, N.J.) · 2020Article
- Functional optical coherence tomography of neurovascular coupling interactions in the retina.Journal of biophotonics · 2018Article
- Functional optical coherence tomography of retinal photoreceptors.Experimental biology and medicine (Maywood, N.J.) · 2018Review
- Light-Induced Length Shrinkage of Rod Photoreceptor Outer Segments.Translational vision science & technology · 2018Article
- Concurrent OCT imaging of stimulus evoked retinal neural activation and hemodynamic responses.Proceedings of SPIE--the International Society for Optical Engineering · 2017Article
- Enhancement of intrinsic optical signal recording with split spectrum optical coherence tomography.Journal of modern optics · 2017Article
- In vivo optical coherence tomography of stimulus-evoked intrinsic optical signals in mouse retinas.Journal of biomedical optics · 2016Article
- Article
- Intrinsic optical signal imaging of retinal physiology: a review.Journal of biomedical optics · 2015Review
- Super-Resolution Scanning Laser Microscopy Based on Virtually Structured Detection.Critical reviews in biomedical engineering · 2015Review
- Dynamic near-infrared imaging reveals transient phototropic change in retinal rod photoreceptors.Journal of biomedical optics · 2013Article
- In vivo confocal intrinsic optical signal identification of localized retinal dysfunction.Investigative ophthalmology & visual science · 2012Article
- Shining light on photoreceptors: A minireview on the development and clinical applications of optoretinography.Taiwan journal of ophthalmologyReview
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Functional measurement is important for retinal study and disease diagnosis. Transient intrinsic optical signal (IOS) response, tightly correlated with functional stimulation, has been previously detected in normal retinas. In this paper, comparative IOS imaging of wild-type (WT) and rod-degenerated mutant mouse retinas is reported. Both 2-month and 1-year-old mice were measured. In 2-month-old mutant mice, time course and peak value of the stimulus-evoked IOS were significantly delayed (relative to stimulus onset) and reduced, respectively, compared to age matched WT mice. In 1-year-old mutant mice, stimulus-evoked IOS was totally absent. However, enhanced spontaneous IOS responses, which might reflect inner neural remodeling in diseased retina, were observed in both 2-month and 1-year-old mutant retinas. Our experiments demonstrate the potential of using IOS imaging for noninvasive and high resolution identification of disease-associated retinal dysfunctions. Moreover, high spatiotemporal resolution IOS imaging may also lead to advanced understanding of disease-associated neural remodeling in the retina.
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Registered trials
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