ArticleEuropean journal of human genetics : EJHG2012
Non-invasive prenatal diagnosis for fetal sex determination: benefits and disadvantages from the service users' perspective.
Article in European journal of human genetics : EJHG, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 84 citations in OpenAlex.
- The experiences and attitudes of hemophilia carriers around pregnancy: A qualitative systematic review.Journal of thrombosis and haemostasis : JTH · 2020Pooled it
- Facilitating informed choice about non-invasive prenatal testing (NIPT): a systematic review and qualitative meta-synthesis of women's experiences.BMC pregnancy and childbirth · 2019Pooled it
- Perspectives of Pregnant People and Clinicians on Noninvasive Prenatal Testing: A Systematic Review and Qualitative Meta-synthesis.Ontario health technology assessment series · 2019Pooled it
- Non-invasive prenatal diagnosis for cystic fibrosis: detection of paternal mutations, exploration of patient preferences and cost analysis.Prenatal diagnosis · 2015Trial
- Providing recurrence risk counselling for parents after diagnosis of a serious genetic condition caused by an apparently de novo mutation in their child: a qualitative investigation of the PREGCARE strategy with UK clinical genetics practitioners.Journal of medical genetics · 2023Article
- Nanoparticle-Enhanced Surface Plasmon Resonance Imaging Enables the Ultrasensitive Detection of Non-Amplified Cell-Free Fetal DNA for Non-Invasive Prenatal Testing.Analytical chemistry · 2022Article
- Genome-Wide Noninvasive Prenatal Diagnosis of De Novo Mutations.Methods in molecular biology (Clifton, N.J.) · 2021Article
- The influence of experiential knowledge and societal perceptions on decision-making regarding non-invasive prenatal testing (NIPT).BMC pregnancy and childbirth · 2020Article
- EMQN best practice guidelines for genetic testing in dystrophinopathies.European journal of human genetics : EJHG · 2020Article
- Clinical management of woman with bleeding disorders: A survey among European haemophilia treatment centres.Haemophilia : the official journal of the World Federation of Hemophilia · 2020Article
- Is preparation a good reason for prenatal genetic testing? Ethical and critical questions.Birth defects research · 2020Article
- Bayesian-based noninvasive prenatal diagnosis of single-gene disorders.Genome research · 2019Article
- Non-invasive Prenatal Diagnosis for BRCA Mutations - a Qualitative Pilot Study of Health Professionals' Views.Journal of genetic counseling · 2016Article
- Limited Clinical Utility of Non-invasive Prenatal Testing for Subchromosomal Abnormalities.American journal of human genetics · 2016Article
- Will the introduction of non-invasive prenatal testing for Down's syndrome undermine informed choice?Health expectations : an international journal of public participation in health care and health policy · 2015Article
- An easy test but a hard decision: ethical issues concerning non-invasive prenatal testing for autosomal recessive disorders.European journal of human genetics : EJHG · 2015Article
- Non-invasive prenatal diagnosis of achondroplasia and thanatophoric dysplasia: next-generation sequencing allows for a safer, more accurate, and comprehensive approach.Prenatal diagnosis · 2015Article
- Cell-free fetal DNA: the new tool in fetal medicine.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2015Article
- Non-invasive prenatal testing: UK genetic counselors' experiences and perspectives.Journal of genetic counseling · 2015Article
- Client views and attitudes to non-invasive prenatal diagnosis for sickle cell disease, thalassaemia and cystic fibrosis.Journal of genetic counseling · 2014Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
Abstract
Prenatal fetal sex determination is clinically indicated for women who are at risk of having a child with a serious genetic disorder affecting a particular sex. Ultrasound has been the traditional method used, but early fetal sex determination using non-invasive prenatal diagnosis (NIPD) can now be performed using cell-free fetal DNA in maternal plasma. The study aim was to assess the views and experiences of service users who had used NIPD for fetal sex determination. In this paper, we report on the perceived benefits and disadvantages. A qualitative approach using semi-structured interviews was used. A total of 44 participants (38 women and 6 partners of participating women) were recruited. Participants' views and experiences of NIPD were overwhelmingly positive. Concerning benefits over traditional methods, three themes emerged: (1) technical aspects of technology; (2) timing; and (3) enhanced decision-making. Practical advantages of NIPD included avoiding miscarriage, and there were a number of psychological advantages associated with timing such as perceived control, early re-engagement, normalization of pregnancy and peace of mind. Participants also valued NIPD as it enabled a stepwise approach to decision-making. A number of disadvantages were discussed including concerns about social sexing and increased bonding at a time in pregnancy when miscarriage risk is high. However, participants felt these were fairly minor in comparison with the advantages of NIPD. Until definitive genetic diagnosis using NIPD is available, NIPD for fetal sex determination is perceived as a good interim measure with a number of notable advantages over traditional methods.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.