ArticleFemale pelvic medicine & reconstructive surgery2010
Systemic effects of vaginally administered estrogen therapy: a review.
Article in Female pelvic medicine & reconstructive surgery, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05457972 (Postpartum Vaginal Estrogen for Sexual Function in Breastfeeding Patients), which is not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Postpartum Vaginal Estrogen for Sexual Function in Breastfeeding Patients: A Randomized Controlled Trial
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The effects of oestrogen on vaginal wound healing: A systematic review and meta-analysis.Neurourology and urodynamics · 2022Pooled it
- Trial
- Trial
- Survival Outcomes in Breast Cancer Patients With Use of Vaginal Estrogen Therapy: A SEER Analysis.JCO oncology practice · 2026Article
- Histological Microstructure and In Vitro Mechanical Properties of Postmenopausal Ewe Perineal Body With and Without Estrogen Replacement Therapy.International urogynecology journal · 2026Article
- Novel liquid-based approaches for transmucosal drug delivery.Acta pharmaceutica Sinica. B · 2026Review
- Impact of estrogen replacement therapy on outcomes following total shoulder arthroplasty: a propensity-matched retrospective cohort study of 1,779 patients.JSES international · 2025Article
- Use of menopausal hormone therapy before and after diagnosis and ovarian cancer survival-A prospective cohort study in Australia.International journal of cancer · 2025Article
- Multifaceted Impact of COHealthcare (Basel, Switzerland) · 2024Article
- Menopausal hormone therapy and risk of sarcoidosis: a population-based nested case-control study in Sweden.European journal of epidemiology · 2024Article
- Testosterone use and sexual function among transgender men and gender diverse people assigned female at birth.American journal of obstetrics and gynecology · 2023Article
- Cost-Effectiveness of perioperative Vaginally Administered estrogen in postmenopausal women undergoing prolapse surgery (EVA trial): study protocol for a multicenter double-blind randomized placebo-controlled trial.BMC women's health · 2021Article
- Practice-changing publications in functional urology: A case-based approach.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2021Article
- Tamoxifen related side effects and their impact on breast cancer incidence: A retrospective analysis of the randomised IBIS-I trial.Breast (Edinburgh, Scotland) · 2020Article
- Mortality and Risk of Cancer After Prophylactic Bilateral Oophorectomy in Women With a Family History of Cancer.JNCI cancer spectrum · 2018Article
- Ospemifene and 4-hydroxyospemifene effectively prevent and treat breast cancer in the MTag.Tg transgenic mouse model.Menopause (New York, N.Y.) · 2012Article
- Local Effects of Vaginally Administered Estrogen Therapy: A Review.Journal of pelvic medicine & surgery · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Hormone therapy was considered the standard of care before the publication of the Women's Health Initiative. After the study was published, the use of systemic hormone therapy dramatically decreased resulting in an increased incidence of menopausal symptoms such as hot flashes, vaginal dryness, and dyspareunia experienced by women. Use of vaginal estrogen offers women a unique alternative for relief of these symptoms. This article reviews the systemic effects of vaginally administered estrogen. Effects on serum hormone levels, vasomotor symptoms, lipid profiles, and use in women with breast cancer are reviewed. An accompanying review (J Pelvic Med Surg. 2009;15:105-114.) examines the local effects of vaginally administered estrogen.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.