ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2012
Sensitivity to cognitive effort mediates psychostimulant effects on a novel rodent cost/benefit decision-making task.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed.
- Effects of methamphetamine on human effort task performance are unrelated to its subjective effects.Psychopharmacology · 2026Trial
- Catecholaminergic modulation of the cost of cognitive control in healthy older adults.PloS one · 2020Trial
- Effects of chemotherapy on cognitive and physical effort-based decision-making tasks in rats.Psychopharmacology · 2026Article
- Behavioral Domain-Specific Effects of Positive Modulation of α5 and α6 GABAPharmacology research & perspectives · 2026Article
- Review
- Shared and distinct features of common effort-based decision-making paradigms and their relation to brain structure and neuropsychiatric conditions: An integrated narrative review.Cognitive, affective & behavioral neuroscience · 2026Review
- Shielding working memory from distraction is more effortful than flexible updating.Scientific reports · 2025Article
- Article
- Insight into differing decision-making strategies that underlie cognitively effort-based decision making using computational modeling in rats.Psychopharmacology · 2024Article
- Amphetamine increases motivation of humans and mice as measured by breakpoint, but does not affect an Electroencephalographic biomarker.Cognitive, affective & behavioral neuroscience · 2024Article
- A Multi-task Platform for Profiling Cognitive and Motivational Constructs in Humans and Nonhuman Primates.bioRxiv : the preprint server for biology · 2023Article
- Amphetamines Improve the Motivation to Invest Effort in Attention-Deficit/Hyperactivity Disorder.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- The motivational role of the ventral striatum and amygdala in learning from gains and losses.Behavioral neuroscience · 2023Article
- Vigor, Effort-Related Aspects of Motivation and Anhedonia.Current topics in behavioral neurosciences · 2022Review
- Electrophysiological biomarkers of behavioral dimensions from cross-species paradigms.Translational psychiatry · 2021Article
- A mosaic of cost-benefit control over cortico-striatal circuitry.Trends in cognitive sciences · 2021Review
- Dose-response effects of d-amphetamine on effort-based decision-making and reinforcement learning.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Contribution of Eye-Tracking to Study Cognitive Impairments Among Clinical Populations.Frontiers in psychology · 2021Article
- Methylphenidate boosts choices of mental labor over leisure depending on striatal dopamine synthesis capacity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- The dopamine depleting agent tetrabenazine alters effort-related decision making as assessed by mouse touchscreen procedures.Psychopharmacology · 2020Article
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4 authors.
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Abstract
Amotivational states and insufficient recruitment of mental effort have been observed in a variety of clinical populations, including depression, traumatic brain injury, post-traumatic stress disorder, and attention deficit hyperactivity disorder. Previous rodent models of effort-based decision making have utilized physical costs whereas human studies of effort are primarily cognitive in nature, and it is unclear whether the two types of effortful decision making are underpinned by the same neurobiological processes. We therefore designed a novel rat cognitive effort task (rCET) based on the 5-choice serial reaction time task, a well-validated measure of attention and impulsivity. Within each trial of the rCET, rats are given the choice between an easy or hard visuospatial discrimination, and successful hard trials are rewarded with double the number of sugar pellets. Similar to previous human studies, stable individual variation in choice behavior was observed, with 'workers' choosing hard trials significantly more than their 'slacker' counterparts. Whereas workers 'slacked off' in response to administration of amphetamine and caffeine, slackers 'worked harder' under amphetamine, but not caffeine. Conversely, these stimulants increased motor impulsivity in all animals. Ethanol did not affect animals' choice but invigorated behavior. In sum, we have shown for the first time that rats are differentially sensitive to cognitive effort when making decisions, independent of other processes such as impulsivity, and these baseline differences can influence the cognitive response to psychostimulants. Such findings could inform our understanding of impairments in effort-based decision making and contribute to treatment development.
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