ReviewThe Kaohsiung journal of medical sciences2012
Mood stabilizers for the treatment of behavioral and psychological symptoms of dementia: an update review.
Review in The Kaohsiung journal of medical sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Efficacy and safety of pharmacotherapy for Alzheimer's disease and for behavioural and psychological symptoms of dementia in older patients with moderate and severe functional impairments: a systematic review of controlled trials.Alzheimer's research & therapy · 2021Pooled it
- Gabapentin and pregabalin to treat aggressivity in dementia: a systematic review and illustrative case report.British journal of clinical pharmacology · 2019Pooled it
- Pragmatic Trial of Personalized Music for Agitation and Antipsychotic Use in Nursing Home Residents With Dementia.Journal of the American Medical Directors Association · 2022Trial
- Cost-utility analysis of cerebrospinal fluid versus blood biomarkers for early detection of Alzheimer's disease and mild cognitive impairment in Thailand: a modeling study.BMC health services research · 2026Article
- Review
- Factors associated with length of stay in patients from residential aged care facilities admitted for behavioural and psychological symptoms of dementia.Australasian journal on ageing · 2025Article
- Sex differences in clinical risk factors for Alzheimer's dementia patients with early-onset and late-onset.Frontiers in global women's health · 2025Article
- Trends in Antiseizure Medication Prescribing Among Nursing Home Residents With and Without a Seizure Diagnosis.The neurologist · 2023Article
- Italian guidance on Dementia Day Care Centres: A position paper.Aging clinical and experimental research · 2023Review
- Long-Stay Mood Stabilizer Use Increasing as Prescription of Antipsychotics Decreases.GeroPsych · 2023Article
- Neuropsychiatric Symptoms in Dementia: Considering a Clinical Role for Electroencephalography.The Journal of neuropsychiatry and clinical neurosciences · 2022Article
- Are Anticholinergic Medications Associated With Increased Risk of Dementia and Behavioral and Psychological Symptoms of Dementia? A Nationwide 15-Year Follow-Up Cohort Study in Taiwan.Frontiers in pharmacology · 2020Article
- Lithium Treatment for Agitation in Alzheimer's disease (Lit-AD): Clinical rationale and study design.Contemporary clinical trials · 2018Article
- Dementia Care at End of Life: Current Approaches.Current psychiatry reports · 2018Review
- Pharmacological management of neuropsychiatric symptoms in patients with major neurocognitive disorders.Journal of psychiatry & neuroscience : JPN · 2018Article
- Treatment of behavioral and psychological symptoms of dementias with psychopharmaceuticals: a review.Neuropsychiatric disease and treatment · 2018Review
- Management of Neuropsychiatric Symptoms in Neurocognitive Disorders.Focus (American Psychiatric Publishing) · 2017Review
- Management of Behavioral and Psychological Symptoms of Dementia.Noro psikiyatri arsivi · 2014Review
- Understanding Long-Stay Gabapentin Use Increases: A National Nursing Home Clinician Survey on Prescribing Intent.Clinical gerontologistArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Behavioral and psychological symptoms of dementia (BPSD) are common and debilitating problems, but current treatments are limited. Antipsychotic agents show some efficacy on BPSD, but their use is limited by the associated risk of cerebrovascular events and mortality. Reports have shown the efficacy of mood stabilizers on BPSD, but systemic reviews on this issue are scant. This article aims to review studies of the efficacy of mood stabilizers on BPSD, and the quality of the available evidence. We searched for articles published in English during the period 1990 to 2010 and included in the PubMed database that concerned treatment of BPSD with mood stabilizers, such as carbamazepine, valproate, gabapentin, topiramate, lamotrigine, oxcarbazepine and lithium. The quality of the studies was assessed by considering the trial designs, analyses, subjects and results. We found one meta-analysis and three randomized controlled trials (RCTs) supporting the efficacy of carbamazepine in managing global BPSD, particularly aggression and hostility. With regard to valproate, current evidence from one meta-analysis and five RCTs did not strongly support its efficacy for global BPSD, including agitation and aggression. Only open trials or case series showed some efficacy of gabapentin, topiramate and lamotrigine in controlling BPSD. The single RCT investigating the effect of oxcarbazepine on agitation and aggression showed negative results. Case series reports on lithium tended to show it to be ineffective. Thus far, among mood stabilizers, carbamazepine has the most robust evidence of efficacy on BPSD. More RCTs are needed to strengthen evidence regarding the efficacy of gabapentin, topiramate and lamotrigine. Valproate, oxcarbazepine and lithium showed low or no evidence of efficacy. Large and well designed RCTs focusing on specific symptoms of BPSD are needed to deal with the issue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.