Trial reportParticle and fibre toxicology2012
Controlled human wood smoke exposure: oxidative stress, inflammation and microvascular function.
Trial report in Particle and fibre toxicology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03104387 (Effects of Diesel Combustion Generated Air Pollution on Cardiovascular Function and Oxidatively Damaged DNA in Healthy Volunteers), which is not on this map. Cited by 46 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Diesel Combustion Generated Air Pollution on Cardiovascular Function and Oxidatively Damaged DNA in Healthy Volunteers
Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 104 citations in OpenAlex.
- Impact of indoor air pollution on DNA damage and chromosome stability: a systematic review.Archives of toxicology · 2024Pooled it
- Non-accidental health impacts of wildfire smoke.International journal of environmental research and public health · 2014Pooled it
- Reduced bronchoalveolar macrophage phagocytosis and cytotoxic effects after controlled short-term exposure to wood smoke in healthy humans.Particle and fibre toxicology · 2023Trial
- Inhalation of hydrogenated vegetable oil combustion exhaust and genotoxicity responses in humans.Archives of toxicology · 2021Trial
- Wood Smoke Exposure Alters Human Inflammatory Responses to Viral Infection in a Sex-Specific Manner. A Randomized, Placebo-controlled Study.American journal of respiratory and critical care medicine · 2019Trial
- Particulate matter exposure and health impacts of urban cyclists: a randomized crossover study.Environmental health : a global access science source · 2018Trial
- No oxidative stress or DNA damage in peripheral blood mononuclear cells after exposure to particles from urban street air in overweight elderly.Mutagenesis · 2015Trial
- The impacts of traffic-related and woodsmoke particulate matter on measures of cardiovascular health: a HEPA filter intervention study.Occupational and environmental medicine · 2015Trial
- Controlled exposure to particulate matter from urban street air is associated with decreased vasodilation and heart rate variability in overweight and older adults.Particle and fibre toxicology · 2015Trial
- Effect of wood smoke exposure on vascular function and thrombus formation in healthy fire fighters.Particle and fibre toxicology · 2014Trial
- Systemic effects of wood smoke in a short-term experimental exposure study of atopic volunteers.Journal of occupational and environmental medicine · 2014Trial
- An indoor air filtration study in homes of elderly: cardiovascular and respiratory effects of exposure to particulate matter.Environmental health : a global access science source · 2013Trial
- Exposure to wood smoke increases arterial stiffness and decreases heart rate variability in humans.Particle and fibre toxicology · 2013Trial
- Towards a validation of the standard and enzyme-linked comet assay: a retrospective variability analysis.Archives of toxicology · 2026Review
- A chamber study of respiratory and autonomic responses to hydrotreated vegetable oil exhaust using ECG-derived respiration.Frontiers in physiology · 2026Article
- Article
- Controlled human exposures: a review and comparison of the health effects of diesel exhaust and wood smoke.Particle and fibre toxicology · 2024Review
- Association Between Serum Levels of Anti-heat Shock Protein 27 Antibody and Liver Cell Injury in Chronic Hepatitis B.Indian journal of clinical biochemistry : IJCB · 2024Article
- Environmental exposure to wildfire smoke may reduce microvascular oxygenation during graded handgrip exercise: A case series.Physiological reports · 2024Article
- Impact of Wildfires on Cardiovascular Health.Circulation research · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExposure to wood smoke is associated with respiratory symptoms, whereas knowledge on systemic effects is limited. We investigated effects on systemic inflammation, oxidative stress and microvascular function (MVF) after controlled wood smoke exposure.
methodsIn a randomised, double-blinded, cross-over study 20 non-smoking atopic subjects were exposed at rest to 14, 220, or 354 μg/m3 of particles from a well-burning modern wood stove for 3 h in a climate controlled chamber with 2 week intervals. We investigated the level of oxidatively damaged DNA, inflammatory markers and adhesion molecules before and 0, 6 and 20 h after exposure. Six h after exposure we measured MVF non-invasively by digital peripheral artery tonometry following arm ischemia.
resultsThe MVF score was unaltered after inhalation of clean air (1.58 ± 0.07; mean ± SEM), low (1.51 ± 0.07) or high (1.61 ± 0.09) concentrations of wood smoke particles in atopic subjects, whereas unexposed non-atopic subjects had higher score (1.91 ± 0.09). The level of oxidatively damaged DNA, mRNA of ITGAL, CCL2, TNF, IL6, IL8, HMOX1, and OGG1 and surface marker molecules ICAM1, ITGAL and L-selectin in peripheral blood mononuclear cells were not affected by inhalation of wood smoke particles.
conclusionsExposure to wood smoke had no effect on markers of oxidative stress, DNA damage, cell adhesion, cytokines or MVF in atopic subjects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.