Evidence map›Paper›PMID 22452818›Full record

ArticleThe Biochemical journal2012

Mousing around with caspases and IAPs.

Robert C Rickert, Guy S Salvesen, Carl F Ware

Abstract readComment
PubMed Publisher
In one paragraph

Article in The Biochemical journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Robert C RickertPrograms in Cell Death and Inflammation Research, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA. robert@sanfordburnham.org
Guy S Salvesen
Carl F Ware

Funding

FUNCTION OF CD19 IN B CELL DEVELOPMENT/DIFFERENTIATIONR01AI041649 · NIAID · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI APGAR, JOHN R · 1998 to 2019
$7.0M
HVEM-BTLA system in InflammationR01AI067890 · NIAID · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI WARE, CARL F · 2007 to 2016
$4.3M
NIAID NIH HHS R01 AI041649NIAID NIH HHS R01 AI067890
6 · The paper itself

Abstract

In a paper in this issue of the Biochemical Journal that questions the role of c-IAP1 (cellular inhibitor of apoptosis 1) in inflammation, new results from the Duckett laboratory remind us of the importance of truly knowing the mice we depend on. It turns out that c-IAP1 is tightly linked to caspase 11 and cannot be segregated by recombination. This disturbing result implies that immune functions ascribed to c-IAP1 may be due to the caspase 11 mutation that is co-inherited with the locus.

Indexed as

MutationAnimalsCaspasesCaspases, InitiatorInhibitor of Apoptosis ProteinsCasp4 protein, mouseCaspasesCaspases, InitiatorInhibitor of Apoptosis Proteins

Identifiers

PMID22452818

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.