ArticleComputer methods in biomechanics and biomedical engineering2014
An experimental and computational analysis of primary cilia deflection under fluid flow.
Article in Computer methods in biomechanics and biomedical engineering, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 48 citations in OpenAlex.
- Shear stress effects on epididymal epithelial cell via primary cilia mechanosensory signaling.Journal of cellular physiology · 2025Article
- Osteocytes and Primary Cilia.Current osteoporosis reports · 2023Review
- Primary cilium: a paradigm for integrating mathematical modeling with experiments and numerical simulations in mechanobiology.Mathematical biosciences and engineering : MBE · 2021Article
- Mechanical Properties of Isolated Primary Cilia Measured by Micro-tensile Test and Atomic Force Microscopy.Frontiers in bioengineering and biotechnology · 2021Article
- Primary cilia have a length-dependent persistence length.Biomechanics and modeling in mechanobiology · 2020Article
- Distinct Roles of TRAPPC8 and TRAPPC12 in Ciliogenesis via Their Interactions With OFD1.Frontiers in cell and developmental biology · 2020Article
- Pulsatile flow through idealized renal tubules: Fluid-structure interaction and dynamic pathologies.Mathematical biosciences and engineering : MBE · 2019Article
- Ciliotherapy Treatments to Enhance Biochemically- and Biophysically-Induced Mesenchymal Stem Cell Osteogenesis: A Comparison Study.Cellular and molecular bioengineering · 2019Article
- TRPV4-mediates oscillatory fluid shear mechanotransduction in mesenchymal stem cells in part via the primary cilium.Scientific reports · 2018Article
- Primary cilia: Cell and molecular mechanosensors directing whole tissue function.Seminars in cell & developmental biology · 2017Review
- The primary cilium is a self-adaptable, integrating nexus for mechanical stimuli and cellular signaling.Biology open · 2015Article
- Mechanical properties of a primary cilium as measured by resonant oscillation.Biophysical journal · 2015Article
- Intracellular and extracellular forces drive primary cilia movement.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Oscillatory fluid flow influences primary cilia and microtubule mechanics.Cytoskeleton (Hoboken, N.J.) · 2014Article
- Primary cilium mechanotransduction of tensile strain in 3D culture: Finite element analyses of strain amplification caused by tensile strain applied to a primary cilium embedded in a collagen matrix.Journal of biomechanics · 2014Article
- An inducible CiliaGFP mouse model for in vivo visualization and analysis of cilia in live tissue.Cilia · 2013Article
- Review
- Dynamics of the primary cilium in shear flow.Biophysical journal · 2012Article
- The primary cilium as a novel extracellular sensor in bone.Frontiers in endocrinology · 2012Article
- The Roles of Primary cilia in Polycystic Kidney Disease.AIMS molecular scienceArticle
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
Abstract
In this study we have developed a novel model of the deflection of primary cilia experiencing fluid flow accounting for phenomena not previously considered. Specifically, we developed a large rotation formulation that accounts for rotation at the base of the cilium, the initial shape of the cilium and fluid drag at high deflection angles. We utilised this model to analyse full 3D data-sets of primary cilia deflecting under fluid flow acquired with high-speed confocal microscopy. We found a wide variety of previously unreported bending shapes and behaviours. We also analysed post-flow relaxation patterns. Results from our combined experimental and theoretical approach suggest that the average flexural rigidity of primary cilia might be higher than previously reported (Schwartz et al. 1997, Am J Physiol. 272(1 Pt 2):F132-F138). In addition our findings indicate that the mechanics of primary cilia are richly varied and mechanisms may exist to alter their mechanical behaviour.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.