ArticleProceedings of the National Academy of Sciences of the United States of America2012
Mutagenesis of pairwise combinations of histone amino-terminal tails reveals functional redundancy in budding yeast.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Investigation of the acetic acid stress response inMicrobial cell (Graz, Austria) · 2023Article
- Direct assessment of histone function using histone replacement.Trends in biochemical sciences · 2023Review
- The role of histone tails in nucleosome stability: An electrostatic perspective.Computational and structural biotechnology journal · 2020Article
- Ethylene induces combinatorial effects of histone H3 acetylation in gene expression in Arabidopsis.BMC genomics · 2017Article
- The amino-terminal tails of histones H2A and H3 coordinate efficient base excision repair, DNA damage signaling and postreplication repair in Saccharomyces cerevisiae.Nucleic acids research · 2015Article
- Chromatin regulation at the frontier of synthetic biology.Nature reviews. Genetics · 2015Review
- High-resolution mapping of H4K16 and H3K23 acetylation reveals conserved and unique distribution patterns in Arabidopsis and rice.Epigenetics · 2015Article
- Proteolytic histone modification by mast cell tryptase, a serglycin proteoglycan-dependent secretory granule protease.The Journal of biological chemistry · 2014Article
- A highly conserved region within H2B is important for FACT to act on nucleosomes.Molecular and cellular biology · 2014Article
- Article
- Case report on the successful removal of an organic penetrating object into the orbit.Journal of injury & violence research · 2014Article
- Contribution of histone N-terminal tails to the structure and stability of nucleosomes.FEBS open bio · 2013Article
- Nucleosomes Regulate Base Excision Repair in Chromatin.Mutation research. Reviews in mutation researchReview
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
A large body of literature provides compelling evidence for the role of evolutionarily conserved core histone residues in various biological processes. However, site-directed mutagenesis of individual residues that are known to be sites of posttranslational modifications often does not result in clear phenotypic defects. In some cases, the combination of multiple mutations can give rise to stronger phenotypes, implying functional redundancy between distinct residues on histones. Here, we examined the "histone redundancy hypothesis" by characterizing double deletion of all pairwise combinations of amino-terminal tails (N-tails) from the four core histones encoded in budding yeast. First, we found that multiple lysine residues on the N-tails of both H2A and H4 are redundantly involved in cell viability. Second, simultaneous deletion of N-tails from H2A and H3 leads to a severe growth defect, which is correlated with perturbed gross chromatin structure in the mutant cells. Finally, by combining point mutations on H3 with deletion of the H2A N-tail, we revealed a redundant role for lysine 4 on H3 and the H2A N-tail in hydroxyurea-mediated response. Altogether, these data suggest that the N-tails of core histones share previously unrecognized, potentially redundant functions that, in some cases are different from those of the widely accepted H2A/H2B and H3/H4 dimer pairs.
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