ArticleThe Canadian journal of infectious diseases = Journal canadien des maladies infectieuses1998
T lymphocyte immunity in host defence against Chlamydia trachomatis and its implication for vaccine development.
Article in The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 37 citations in OpenAlex.
- Cellular Basis for the Enhanced Efficacy of the Fms-Like Tyrosine Kinase 3 Ligand (FL) Adjuvanted VCG-BasedFrontiers in immunology · 2021Article
- Shift work influences the outcomes of Chlamydia infection and pathogenesis.Scientific reports · 2020Article
- Respective IL-17A production by γδ T and Th17 cells and its implication in host defense against chlamydial lung infection.Cellular & molecular immunology · 2017Article
- NK-DC Crosstalk in Immunity to Microbial Infection.Journal of immunology research · 2016Review
- Article
- Monitoring the T cell response to genital tract infection.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Article
- Inflammation and clearance of Chlamydia trachomatis in enteric and nonenteric mucosae.Infection and immunity · 2001Article
- Induction of protective immunity against Chlamydia trachomatis genital infection by a vaccine based on major outer membrane protein-lipophilic immune response-stimulating complexes.Infection and immunity · 2000Article
- Priming with Chlamydia trachomatis major outer membrane protein (MOMP) DNA followed by MOMP ISCOM boosting enhances protection and is associated with increased immunoglobulin A and Th1 cellular immune responses.Infection and immunity · 2000Article
- Chlamydia trachomatis (mouse pneumonitis strain) induces cardiovascular pathology following respiratory tract infection.Infection and immunity · 1999Article
- Immunity to Chlamydia trachomatis mouse pneumonitis induced by vaccination with live organisms correlates with early granulocyte-macrophage colony-stimulating factor and interleukin-12 production and with dendritic cell-like maturation.Infection and immunity · 1999Article
- Characterization of immune responses following intramuscular DNA immunization with the MOMP gene of Chlamydia trachomatis mouse pneumonitis strain.Immunology · 1999Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chlamydia trachomatis is an obligate intracellular bacterial pathogen that causes several significant human infectious diseases, including trachoma, urethritis, cervicitis and salpingitis, and is an important cofactor for transmission of human immunodeficiency virus. Until very recently, over three decades of research effort aimed at developing a C trachomatis vaccine had failed, due mainly to the lack of a precise understanding of the mechanisms for protective immunity. Although most studies concerning protective immunity to C trachomatis have focused on humoral immune responses, recent studies have clearly shown that T helper-1 (Th1)-like CD4 T cell-mediated immune responses play the dominant role in protective immunity. These studies suggest a paradigm for chlamydial immunity and pathology based on the concept of heterogeneity (Th1/Th2) in CD4 T cell immune responses. This concept for chlamydial immunity offers a rational template on which to base renewed efforts for development of a chlamydial vaccine that targets the induction of cell-mediated Th1 immune responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.