ArticleJournal of experimental botany2012
Hypoxia induces H2O2 production and activates antioxidant defence system in grapevine buds through mediation of H2O2 and ethylene.
Article in Journal of experimental botany, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed, 116 citations in OpenAlex.
- Exogenous γ-aminobutyric acid application delays onset of ripening in Grenache, Chardonnay, and Shiraz grape berries.Plant & cell physiology · 2026Article
- Ethylene signalling enhances mitochondrial stress tolerance independently of the transcription factor ANAC017 in Arabidopsis.Journal of experimental botany · 2026Article
- Cane water content regulates grapevine (Vitis vinifera L.) winter bud dormancy via ros homeostasis and antioxidant enzyme system.Molecular biology reports · 2026Article
- The Role of tRNA Fragments on Neurogenesis Alteration by H₂O₂-induced Oxidative Stress.Journal of molecular neuroscience : MN · 2025Article
- Conditional Control of Benzylguanine Reaction with the Self-Labeling SNAP-tag Protein.Bioconjugate chemistry · 2025Article
- Suppression of photorespiratory metabolism by low OPhysiology and molecular biology of plants : an international journal of functional plant biology · 2023Article
- Nanodrug rescues liver fibrosis via synergistic therapy with HCommunications biology · 2023Article
- Comparative transcriptome analysis of genes involved in paradormant bud release response in 'Summer Black' grape.Frontiers in plant science · 2023Article
- The bud dormancy disconnect: latent buds of grapevine are dormant during summer despite a high metabolic rate.Journal of experimental botany · 2022Article
- Emerging Roles of γ Aminobutyric Acid (GABA) Gated Channels in Plant Stress Tolerance.Plants (Basel, Switzerland) · 2021Review
- Salt-tolerance screening in Limonium sinuatum varieties with different flower colors.Scientific reports · 2021Article
- Hydrogen Peroxide Increases during Endodormancy and Decreases during Budbreak in Grapevine (Antioxidants (Basel, Switzerland) · 2021Article
- Phenoloxidases in Plants-How Structural Diversity Enables Functional Specificity.Frontiers in plant science · 2021Review
- Photocontrol of Axillary Bud Outgrowth by MicroRNAs: Current State-of-the-Art and Novel Perspectives Gained From the Rosebush Model.Frontiers in plant science · 2021Article
- Ascorbate glutathione-dependent H2O2 scavenging is an important process in axillary bud outgrowth in rosebush.Annals of botany · 2020Article
- Review
- The Seedlings of DifferentPlants (Basel, Switzerland) · 2020Article
- Hydrogen peroxide alleviates salinity-induced damage through enhancing proline accumulation in wheat seedlings.Plant cell reports · 2020Article
- Roles for Plant Mitochondrial Alternative Oxidase Under Normoxia, Hypoxia, and Reoxygenation Conditions.Frontiers in plant science · 2020Article
- Hydrogen cyanamide induces grape bud endodormancy release through carbohydrate metabolism and plant hormone signaling.BMC genomics · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Paradoxically, in eukaryotic cells, hydrogen peroxide (H(2)O(2)) accumulates in response to oxygen deprivation (hypoxia). The source of H(2)O(2) under hypoxia varies according to the species, organs, and tissue. In non-photosynthetic tissues, H(2)O(2) is mainly produced by activation of NAD(P)H-oxidases or by disruption of the mitochondrial electron transport chain (m-ETC). This study showed that hypoxia, and inhibitors of respiration like potassium cyanide (KCN) and sodium nitroprusside (SNP), trigger the production of H(2)O(2) in grapevine buds. However, diphenyleneiodonium, an inhibitor of NAD(P)H-oxidase, did not reduce the H(2)O(2) levels induced by KCN, suggesting that, under respiratory stress, H(2)O(2) is mainly produced by disruption of the m-ETC. On the other hand, γ-aminobutyric acid (GABA), a metabolite that in plants alleviates oxidative stress by activating antioxidant enzymes, reduced significantly the levels of H(2)O(2) induced by KCN and, surprisingly, repressed the expression of genes encoding antioxidant enzymes such as ASCORBATE PEROXIDASE (VvAPX), GLUTATHIONE PEROXIDASE (VvGLPX), SUPEROXIDE DISMUTASE (VvSOD), and one of the CATALASE isoforms (VvCAT1), while VvCAT2 was upregulated. In contrast to GABA, hypoxia, H(2)O(2), and ethylene increased dramatically the expression of genes encoding antioxidant enzymes and enzymes of the alternative respiratory pathway such as ALTERNATIVE NADH-DEHYDROGENASES (VvaNDs) and ALTERNATIVE OXIDASES (VvAOXs). Hence, it is concluded that H(2)O(2) production is stimulated by respiratory stress in grapevine buds, that H(2)O(2) and ethylene act as signalling molecules and activate genes related to the antioxidant defence system, and finally that GABA reduces H(2)O(2) levels by up-regulating the expression of VvCAT2.
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