ArticleJournal of dental research2012
Posterior insular molecular changes in myofascial pain.
Article in Journal of dental research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- The neuro-pathophysiology of temporomandibular disorders-related pain: a systematic review of structural and functional MRI studies.The journal of headache and pain · 2020Pooled it
- Gray matter alterations in chronic pain: A network-oriented meta-analytic approach.NeuroImage. Clinical · 2014Pooled it
- Pooled it
- Neural Mechanisms and Brain Alterations in Orofacial Pain: A Narrative Review of Human Neuroimaging.Diagnostics (Basel, Switzerland) · 2026Review
- Neuroimaging and artificial intelligence for assessment of chronic painful temporomandibular disorders-a comprehensive review.International journal of oral science · 2023Review
- Disrupted Spontaneous Neural Activity and Its Interaction With Pain and Emotion in Temporomandibular Disorders.Frontiers in neuroscience · 2022Article
- White Matter Diffusion Properties in Chronic Temporomandibular Disorders: An Exploratory Analysis.Frontiers in pain research (Lausanne, Switzerland) · 2022Article
- Topology of pain networks in patients with temporomandibular disorder and pain-free controls with and without concurrent experimental pain: A pilot study.Frontiers in pain research (Lausanne, Switzerland) · 2022Article
- Altered brain responses to noxious dentoalveolar stimuli in high-impact temporomandibular disorder pain patients.PloS one · 2022Article
- Effects of centric mandibular splint therapy on orofacial pain and cerebral activation patterns.Clinical oral investigations · 2020Article
- Biomarkers in Temporomandibular Disorder and Trigeminal Neuralgia: A Conceptual Framework for Understanding Chronic Pain.Canadian journal of pain = Revue canadienne de la douleur · 2020Article
- Temporomandibular inflammation mobilizes parvalbumin and FosB/deltaFosB neurons of amygdala and dorsal raphe.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2020Article
- Article
- Reduced corticostriatal functional connectivity in temporomandibular disorders.Human brain mapping · 2018Article
- Article
- The usefulness of diagnostic imaging for the assessment of pain symptoms in temporomandibular disorders.The Japanese dental science review · 2016Review
- Multivariate classification of pain-evoked brain activity in temporomandibular disorder.Pain reports · 2016Article
- Pain Mechanisms and Centralized Pain in Temporomandibular Disorders.Journal of dental research · 2016Review
- Neuroimaging of Central Sensitivity Syndromes: Key Insights from the Scientific Literature.Current rheumatology reviews · 2016Review
- GABA and glutamate levels in occlusal splint-wearing males with possible bruxism.Archives of oral biology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Temporomandibular disorders (TMD) include craniocervical pain conditions with unclear etiologies. Central changes are suspected; however, few neuroimaging studies of TMD exist. Single-voxel proton magnetic resonance spectroscopy ((1)H-MRS) was used before and after pressure-pain testing to assess glutamate (Glu), glutamine (Gln), N-acetylaspartate (NAA), and choline (Cho) levels in the right and left posterior insulae of 11 individuals with myofascial TMD and 11 matched control individuals. Glu levels were significantly lower in all individuals after pain testing. Among those with TMD, left-insular Gln levels were related to reported pain, left posterior insular NAA and Cho levels were significantly higher at baseline than in control individuals, and NAA levels were significantly correlated with pain-symptom duration, suggesting adaptive changes. The results suggest that significant central cellular and molecular changes can occur in individuals with TMD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.