Trial reportThe journals of gerontology. Series A, Biological sciences and medical sciences2012
Total and abdominal adiposity are associated with inflammation in older adults using a factor analysis approach.
Trial report in The journals of gerontology. Series A, Biological sciences and medical sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 50 citations in OpenAlex.
- Trial
- Association between inflammatory markers, body composition and frailty in home-dwelling elderly: an 8-year follow-up study.GeroScience · 2024Article
- A Study of Physical Resilience and Aging (SPRING): Conceptual framework, rationale, and study design.Journal of the American Geriatrics Society · 2023Article
- Age-Related Study of Anthropometry Indicators, Body Composition, Strength and Vital Capacity at Masters Athletics: How to Postpone Sarcopenia.Clinical interventions in aging · 2023Article
- From Obesity to Diabetes: The Role of the Adipose Organ.Handbook of experimental pharmacology · 2022Review
- Aging, obesity, sarcopenia and the effect of diet and exercise intervention.Experimental gerontology · 2021 · on this mapReview
- Review
- Associations of dietary inflammatory index, serum levels of MCP-1 and body composition in Iranian overweight and obese women: a cross-sectional study.BMC research notes · 2020Article
- Phenotypes of Sarcopenic Obesity: Exploring the Effects on Peri-Muscular Fat, the Obesity Paradox, Hormone-Related Responses and the Clinical Implications.Geriatrics (Basel, Switzerland) · 2020Review
- Gender-specific association of body composition with inflammatory and adipose-related markers in healthy elderly Europeans from the NU-AGE study.European radiology · 2019Article
- Inflammation and quality of life in later life: findings from the health, well-being and aging study (SABE).Health and quality of life outcomes · 2019Article
- Article
- Impact of chemotherapy on medium-term physical function and activity of older breast cancer survivors, and associated biomarkers.Journal of geriatric oncology · 2017Article
- Overweight and Abdominal Obesity Association with All-Cause and Cardiovascular Mortality in the Elderly Aged 80 and Over: A Cohort Study.The journal of nutrition, health & aging · 2017Article
- Physical impairment and body weight history in postmenopausal women: the Women's Health Initiative.Public health nutrition · 2016Article
- Interleukin-6 and C-reactive protein, successful aging, and mortality: the PolSenior study.Immunity & ageing : I & A · 2016Article
- Caloric restriction for treatment of geriatric obesity: Do the benefits outweigh the risks?Current nutrition reports · 2015Article
- Circulating Lp-PLA₂ activity correlates with oxidative stress and cytokines in overweight/obese postmenopausal women not using hormone replacement therapy.Age (Dordrecht, Netherlands) · 2015Article
- Aging exacerbates obesity-induced cerebromicrovascular rarefaction, neurovascular uncoupling, and cognitive decline in mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2014Article
- Obesity in aging exacerbates blood-brain barrier disruption, neuroinflammation, and oxidative stress in the mouse hippocampus: effects on expression of genes involved in beta-amyloid generation and Alzheimer's disease.The journals of gerontology. Series A, Biological sciences and medical sciences · 2014Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundObesity-related increases in multiple inflammatory markers may contribute to the persistent subclinical inflammation common with advancing age. However, it is unclear if a specific combination of markers reflects the underlying inflammatory state. We used factor analysis to identify inflammatory factor(s) and examine their associations with adiposity in older adults at risk for disability.
methodsAdiponectin, CRP, IL-1ra, IL-1sRII, IL-2sRα, IL-6, IL-6sR, IL-8, IL-15, sTNFRI, sTNFRII, and TNF-α were measured in 179 participants from the Lifestyle Interventions and Independence for Elders Pilot (Mean ± SD age 77 ± 4 years, 76% white, 70% women). Body mass index, waist circumference, and total fat mass were assessed by anthropometry and dual-energy x-ray absorptiometry.
resultsIL-2sRα, sTNFRI, and sTNFRII loaded highest on the first factor (factor 1). CRP, IL-1ra, and IL-6 loaded highest on the second factor (factor 2). Factor 2, but not factor 1, was positively associated with 1-SD increments in waist circumference (β = 0.160 ± 0.057, p = .005), body mass index (β = 0.132 ± 0.053, p = .01), and total fat mass (β = 0.126 ± 0.053, p = .02) after adjusting for age, gender, race/ethnicity, site, smoking, anti-inflammatory medications, comorbidity index, health-related quality of life, and physical function. These associations remained significant after further adjustment for grip strength, but only waist circumference remained associated with inflammation after adjusting for total lean mass. There were no significant interactions between adiposity and muscle mass or strength for either factor.
conclusionsGreater total and abdominal adiposity are associated with higher levels of an inflammatory factor related to CRP, IL-1ra, and IL-6 in older adults, which may provide a clinically useful measure of inflammation in this population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.