ArticleJournal of Alzheimer's disease : JAD2012
Antemortem pulse pressure elevation predicts cerebrovascular disease in autopsy-confirmed Alzheimer's disease.
Article in Journal of Alzheimer's disease : JAD, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Hypertension and Alzheimer's disease pathology at autopsy: A systematic review.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Pooled it
- Age differences in spontaneous cerebrovascular reactivity at rest.GeroScience · 2026Article
- Elevated levels of circulating plasma sPDGFRβ in cognitively impaired APOE4 carriers.GeroScience · 2026Article
- Cerebral hypoperfusion, brain structural integrity, and cognitive impairment in older APOE4 carriers.GeroScience · 2025Article
- Perifoveal Choriocapillaris Flow Deficits Associated With Cerebrospinal Fluid Aβ42/tau in Presymptomatic Alzheimer's Disease.Translational vision science & technology · 2025Article
- Effect Modifiers of the Association of Blood Pressure With Brain Amyloid and Tau Pathology.Neurology · 2025Article
- Spontaneous cerebrovascular reactivity at rest in older adults with and without mild cognitive impairment and memory deficits.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Sex differences in the association of cardiometabolic risk scores and blood pressure measurements with white matter hyperintensities in diverse older adults-HABS-HD.Frontiers in aging neuroscience · 2025Article
- Estimated Pulse Wave Velocity Is Associated With a Higher Risk of Dementia in the Health and Retirement Study.American journal of hypertension · 2024Article
- Spontaneous cerebrovascular reactivity at rest in older adults with and without mild cognitive impairment and memory deficits.medRxiv : the preprint server for health sciences · 2024Article
- Vascular risk burden is a key player in the early progression of Alzheimer's disease.Neurobiology of aging · 2024Article
- Choriocapillaris and Retinal Vascular Alterations in Presymptomatic Alzheimer's Disease.Investigative ophthalmology & visual science · 2024Article
- A pathway linking pulse pressure to dementia in adults with Down syndrome.Brain communications · 2024Article
- Pulse pressure and APOE ε4 dose interact to affect cerebral blood flow in older adults without dementia.Cerebral circulation - cognition and behavior · 2024Article
- Pathways linking pulse pressure to dementia in adults with Down syndrome.medRxiv : the preprint server for health sciences · 2023Article
- Visit-To-Visit Blood Pressure Variability and Subthreshold Depressive Symptoms in Older Adults.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2022Article
- Paradoxical cognitive trajectories in men from earlier to later adulthood.Neurobiology of aging · 2022Article
- Interactive Effects of Pulse Pressure and Tau Imaging on Longitudinal Cognition.Journal of Alzheimer's disease : JAD · 2022Article
- Antemortem Visit-To-Visit Blood Pressure Variability Predicts Cerebrovascular Lesion Burden in Autopsy-Confirmed Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2021Article
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Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Elevated pulse pressure (PP) is associated with cognitive decline and increased risk of Alzheimer's disease (AD) in older adults, although the mechanisms behind these associations remain unclear. To address this question, we examined whether antemortem late-life PP elevation predicted vascular or AD pathology in autopsy-confirmed AD patients. Sixty-five elderly patients (mean age 74.2 years) clinically diagnosed with possible or probable AD underwent neuropsychological testing and blood pressure examinations. Postmortem histopathological measures of cerebrovascular disease (CVD) and AD neuropathology were later obtained on these same patients. We expected that antemortem PP elevation, but not standard blood pressure measures such as systolic or diastolic blood pressure, would predict the autopsy-based presence of CVD, and possibly AD pathology, in elderly AD patients. Results demonstrated that antemortem PP elevation was associated with the presence and severity of CVD at autopsy. For every 5 mmHg increase in antemortem PP there was an estimated 36% increase in the odds of having CVD at autopsy. Additionally, PP accounted for 12% of variance in CVD severity. No significant associations were present for cerebral amyloid angiopathy or Braak and Braak staging of the severity of AD pathology. Other standard blood pressure measures also did not significantly predict neuropathology. The association between antemortem PP and CVD at autopsy suggests that in older adults with AD, PP elevation may increase the risk of CVD. These findings may have treatment implications since some antihypertensive medications specifically address the pulsatile component of blood pressure (e.g., renin-angiotensin system inhibitors, calcium channel blockers).
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Registered trials
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