ArticleCalcified tissue international2012
Mid-thigh cortical bone structural parameters, muscle mass and strength, and association with lower limb fractures in older men and women (AGES-Reykjavik Study).
Article in Calcified tissue international, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Human Relevance of Preclinical Studies on the Skeletal Impact of Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis.Calcified tissue international · 2021Pooled it
- Extensive differential gene expression and regulation by sex in human skeletal muscle.Cell genomics · 2025Article
- Milk intake and hip fracture incidence in community-dwelling old Icelandic adults.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023Article
- Clinical Utility of Thigh and Mid-Thigh Dual-Energy x-Ray Absorptiometry to Identify Bone and Muscle Loss.JBMR plus · 2023Article
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- Effects of competitive physical activity on serum irisin levels and bone turnover markers.Journal of endocrinological investigation · 2021Article
- Acute fat loss does not affect bone mass.Scientific reports · 2021Article
- Accelerated decline in quadriceps area and Timed Up and Go test performance are associated with hip fracture risk in older adults with impaired kidney function.Experimental gerontology · 2021Article
- Computed tomography-based skeletal muscle and adipose tissue attenuation: Variations by age, sex, and muscle.Experimental gerontology · 2021Article
- Parkinson's disease and osteoporosis: basic and clinical implications.Expert review of endocrinology & metabolism · 2020Review
- Thirty years of translational research in Mobility Medicine: Collection of abstracts of the 2020 Padua Muscle Days.European journal of translational myology · 2020Article
- Myosteatosis in the Context of Skeletal Muscle Function Deficit: An Interdisciplinary Workshop at the National Institute on Aging.Frontiers in physiology · 2020Review
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- Associations of Quadriceps Torque Properties with Muscle Size, Attenuation, and Intramuscular Adipose Tissue in Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2018Article
- Advanced quantitative methods in correlating sarcopenic muscle degeneration with lower extremity function biometrics and comorbidities.PloS one · 2018Article
- Associations of 24-hour sleep duration and CT-derived measurements of muscle and bone: The AGES-Reykjavik Study.Experimental gerontology · 2017Article
- Associations of fat and muscle tissue with cognitive status in older adults: the AGES-Reykjavik Study.Age and ageing · 2017Article
- High risk of fall, poor physical function, and low grip strength in men with fracture-the STRAMBO study.Journal of cachexia, sarcopenia and muscle · 2016Article
- Muscle Quality and Myosteatosis: Novel Associations With Mortality Risk: The Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study.American journal of epidemiology · 2016Article
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Authors and funding
10 authors.
Funding
Abstract
In a cross-sectional study we investigated the relationship between muscle and bone parameters in the mid-thigh in older people using data from a single axial computed tomographic section through the mid-thigh. Additionally, we studied the association of these variables with incident low-trauma lower limb fractures. A total of 3,762 older individuals (1,838 men and 1,924 women), aged 66-96 years, participants in the AGES-Reykjavik study, were studied. The total cross-sectional muscular area and knee extensor strength declined with age similarly in both sexes. Muscle parameters correlated most strongly with cortical area and total shaft area (adjusted for age, height, and weight) but explained <10 % of variability in those bone parameters. The increment in medullary area (MA) and buckling ratio (BR) with age was almost fourfold greater in women than men. The association between MA and muscle parameters was nonsignificant. During a median follow-up of 5.3 years, 113 women and 66 men sustained incident lower limb fractures. Small muscular area, low knee extensor strength, large MA, low cortical thickness, and high BR were significantly associated with fractures in both sexes. Our results show that bone and muscle loss proceed at different rates and with different gender patterns.
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