Evidence map›Paper›PMID 22451193›Full record

ReviewCurrent allergy and asthma reports2012

Epigenetics, asthma, and allergic diseases: a review of the latest advancements.

Stephanie Lovinsky-Desir, Rachel L Miller

Abstract readReview
In one paragraph

Review in Current allergy and asthma reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Epigenome-wide association studies of allergic disease and the environment.The Journal of allergy and clinical immunology · 2023
    Review
  7. Article
  8. Review
  9. Epigenetic Dysregulation in Autoimmune and Inflammatory Skin Diseases.Clinical reviews in allergy & immunology · 2022
    Review
  10. Article
  11. Review
  12. Review
  13. Genetics and Epigenetics in Asthma.International journal of molecular sciences · 2021
    Review
  14. MicroRNA Targets for Asthma Therapy.Advances in experimental medicine and biology · 2021
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Stephanie Lovinsky-DesirDivision of Pediatric Pulmonary, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA. stl2003@nyp.org
Rachel L Miller

Funding

Windows of Susceptibility to PAH/DEP Exposure and AsthmaP50ES015905 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PERERA, FREDERICA P · 2007 to 2011
$10.3M
Urban Diesel Exposure and Inner City AsthmaR01ES013163 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MILLER, RACHEL L · 2005 to 2016
$6.5M
The Columbia University Training Program in Lung ScienceT32HL105323 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Jahar Bhattacharya, Wellington V. Cardoso · 2011 to 2026
$4.7M
NHLBI NIH HHS T32 HL105323NIEHS NIH HHS P50 ES015905NIEHS NIH HHS R01 ES013163
6 · The paper itself

Abstract

Environmental epigenetic regulation in asthma and allergic disease is an exciting area that has gained a great deal of scientific momentum in recent years. Environmental exposures, including prenatal maternal smoking, have been associated with asthma-related outcomes that may be explained by epigenetic regulation. In addition, several known allergy and asthma genes have been found to be susceptible to epigenetic regulation. We review the latest experimental and translational studies that have been published this past year in several areas, including 1) characterization of environmental asthma triggers that induce epigenetic changes, 2) characterization of allergic immune and regulatory pathways important to asthma that undergo epigenetic regulation, 3) evidence of active epigenetic regulation in asthma experimental models and the production of asthma biomarkers, 4) evidence of transmission of an asthma-related phenotype across multiple generations, and 5) "pharmaco-epigenetics." The field has certainly advanced significantly in the past year.

Indexed as

Epigenesis, GeneticGene-Environment InteractionAir PollutionAnimalsAsthmaBiomarkersDisease Models, AnimalDisease SusceptibilityDNA MethylationEnvironmental ExposureEpigenomicsHistonesHumansHypersensitivityPharmacogeneticsPhenotypeBiomarkersHistonesRNA, Messenger

Identifiers

PMID22451193
PMCPMC3358775

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.