ArticlePathology oncology research : POR2012
Characterization of the human papillomavirus (HPV) integration sites into genital cancers.
Article in Pathology oncology research : POR, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 31 citations in OpenAlex.
- The role of HR-HPV integration in the progression of premalignant lesions into different cancer types.Heliyon · 2024Review
- HPV DNA Integration at Actionable Cancer-Related Genes Loci in HPV-Associated Carcinomas.Cancers · 2024Article
- Human Papillomavirus Status in Primary Lesions and Pelvic Lymph Nodes and Its Prognostic Value in Cervical Cancer Patients with Lymph Node Metastases.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Biological Characteristics of Cervical Precancerous Cell Proliferation.Open medicine (Warsaw, Poland) · 2019Article
- Single-cell whole-genome sequencing identifies human papillomavirus integration in cervical tumour cells prior to and following radiotherapy.Oncology letters · 2018Article
- Relationship between human papillomavirus and penile cancer-implications for prevention and treatment.Translational andrology and urology · 2017Review
- 2016 International meeting of the Global Virus Network.Antiviral research · 2017Article
- Genomic characterization of viral integration sites in HPV-related cancers.International journal of cancer · 2016Article
- Detection of human papillomavirus DNA in peri-tumor tissues and pelvic lymph nodes as potential molecular marker of micrometastasis in cervical cancer.Infectious agents and cancer · 2016Article
- Infection and integration of high-risk human papillomavirus in HPV-associated cancer cells.Medical oncology (Northwood, London, England) · 2015Article
- TP53 and PIK3CA gene mutations in adenocarcinoma, squamous cell carcinoma and high-grade intraepithelial neoplasia of the cervix.Journal of translational medicine · 2014Article
- Somatic mutations of STK11 gene in human papillomavirus positive and negative penile cancer.Infectious agents and cancer · 2013Article
- Viral and cellular biomarkers in the diagnosis of cervical intraepithelial neoplasia and cancer.BioMed research international · 2013Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oncogenic HPVs have been found frequently integrated into human genome of invasive cancers and chromosomal localization has been extensively investigated in cervical carcinoma. Few studies have analyzed the HPV integration loci in other genital cancers. We have characterized the integration sites of HPV16 in invasive penile carcinoma by means of Alu-HPV-based PCR. Nucleotide sequence analysis of viral-human DNA junctions showed that HPV integration occurred in one case within the chromosome 8q21.3 region, in which the FAM92A1 gene is mapped, and in the second case inside the chromosome 16p13.3, within the intronic region of TRAP1 gene. These results confirm previous observations, summarized in a systematic review of the literature, on the HPV integration events in gene loci relevant to cancer pathogenesis.
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