ArticleMedical microbiology and immunology2012
Bartonella vinsonii subsp. berkhoffii and Bartonella henselae as potential causes of proliferative vascular diseases in animals.
Article in Medical microbiology and immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 54 citations in OpenAlex.
- Case Report: Systemic reactive angioendotheliomatosis in a young cat with a history of esophageal strictures and balloon dilations.Frontiers in veterinary science · 2026Article
- Article
- Infectious endocarditis caused by Bartonella henselae associated with infected pets: two case reports.Journal of medical case reports · 2023Article
- Detection ofEmerging microbes & infections · 2022Article
- Bartonella spp. seroepidemiology and associations with clinicopathologic findings in dogs in the United States.Journal of veterinary internal medicine · 2022Article
- Canine and Feline Parasitology: Analogies, Differences, and Relevance for Human Health.Clinical microbiology reviews · 2021Review
- Development of a Multiplex Droplet Digital PCR Assay for the Detection ofPathogens (Basel, Switzerland) · 2021Article
- Long COVID or Post-acute Sequelae of COVID-19 (PASC): An Overview of Biological Factors That May Contribute to Persistent Symptoms.Frontiers in microbiology · 2021Review
- Hopping species and borders: detection of Bartonella spp. in avian nest fleas and arctic foxes from Nunavut, Canada.Parasites & vectors · 2020Article
- Article
- Bartonella infections in cats and dogs including zoonotic aspects.Parasites & vectors · 2018Review
- Evaluation of cell culture-grown Bartonella antigens in immunofluorescent antibody assays for the serological diagnosis of bartonellosis in dogs.Journal of veterinary internal medicine · 2018Article
- Bartonella Seroepidemiology in Dogs from North America, 2008-2014.Journal of veterinary internal medicine · 2018Article
- First description of Bartonella koehlerae infection in a Spanish dog with infective endocarditis.Parasites & vectors · 2017Article
- Molecular detection of vector-borne pathogens in blood and splenic samples from dogs with splenic disease.Parasites & vectors · 2017Article
- Did Bartonella henselae contribute to the deaths of two veterinarians?Parasites & vectors · 2015Article
- Zoonotic Bartonella species in cardiac valves of healthy coyotes, California, USA.Emerging infectious diseases · 2014Article
- Bartonella henselae bacteremia in a mother and son potentially associated with tick exposure.Parasites & vectors · 2013Article
- Infection of human brain vascular pericytes (HBVPs) by Bartonella henselae.Medical microbiology and immunology · 2013Article
- Koch's postulates and the pathogenesis of comparative infectious disease causation associated with Bartonella species.Journal of comparative pathology · 2013Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bartonella species are highly fastidious, vector borne, zoonotic bacteria that cause persistent intraerythrocytic bacteremia and endotheliotropic infection in reservoir and incidental hosts. Based upon prior in vitro research, three Bartonella sp., B. bacilliformis, B. henselae, and B. quintana can induce proliferation of endothelial cells, and each species has been associated with in vivo formation of vasoproliferative tumors in human patients. In this study, we report the molecular detection of B. vinsonii subsp. berkhoffii, B. henselae, B. koehlerae, or DNA of two of these Bartonella species simultaneously in vasoproliferative hemangiopericytomas from a dog, a horse, and a red wolf and in systemic reactive angioendotheliomatosis lesions from cats and a steer. In addition, we provide documentation that B. vinsonii subsp. berkhoffii infections induce activation of hypoxia inducible factor-1 and production of vascular endothelial growth factor, thereby providing mechanistic evidence as to how these bacteria could contribute to the development of vasoproliferative lesions. Based upon these results, we suggest that a fourth species, B. vinsonii subsp. berkhoffii, should be added to the list of bartonellae that can induce vasoproliferative lesions and that infection with one or more Bartonella sp. may contribute to the pathogenesis of systemic reactive angioendotheliomatosis and hemangiopericytomas in animals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.