ArticleMolecules (Basel, Switzerland)2012
Extracts of Lycoris aurea induce apoptosis in murine sarcoma S180 cells.
Article in Molecules (Basel, Switzerland), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 26 citations in OpenAlex.
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- Identification, molecular characterization and expression of JAZ genes in Lycoris aurea.PloS one · 2020Article
- Antiproliferative activities of Amaryllidaceae alkaloids from Lycoris radiata targeting DNA topoisomerase I.Scientific reports · 2016Article
- Mechanism of apoptosis induction in human hepatocellular carcinoma cells following treatment with a gecko peptides mixture.Biomedical reports · 2016Article
- Comparative Analysis of Amaryllidaceae Alkaloids from Three Lycoris Species.Molecules (Basel, Switzerland) · 2015Article
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- Anti-tumor effects of atractylenolide I isolated from Atractylodes macrocephala in human lung carcinoma cell lines.Molecules (Basel, Switzerland) · 2013Article
- A new Amaryllidaceae alkaloid from the bulbs of Lycoris radiata.Chinese journal of natural medicines · 2013Article
- De novo sequence assembly and characterization of Lycoris aurea transcriptome using GS FLX titanium platform of 454 pyrosequencing.PloS one · 2013Article
- In vitro and in vivo antitumor effect of trachylobane-360, a diterpene from Xylopia langsdorffiana.Molecules (Basel, Switzerland) · 2012Article
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4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Lycoris species have been known since long ago as a multi-utility ethnomedicinal herbal in China. It has been reported to exhibit a number of properties such as anticancer, neuroprotective, and antibacterial activities. In the present study, the anticancer efficacy of dichloromethane extracts of Lycoris aurea (DELA), was evaluated both in vivo and in vitro using murine sarcoma 180 cells. To evaluate the effects of DELA on apoptotic cell death, flow cytometry and Western blotting were performed. DELA demonstrated promising inhibition effects on sarcoma 180 cells in vitro and a 53.49% inhibitory rate on cancer cells in vivo. DELA treatment increased thymus indices and spleen indices in vivo, indicating that it reduced tumours, but did not damage the main immune organs. The DELA-evoked increase in apoptotic cell death was accompanied by occurrence of cleaved caspase-3 and decreases in the ratio of Bcl-2/Bax. Further purification and LCMS analysis showed DELA contained homolycorine, 2α-hydroxyoduline, oduline, hippeastrine, 2α-hydroxy-6-O- methyloduline, and 2α-methoxy-6-O-methyloduline. These results indicate that DELA exerted its anticancer effects, at least in part, by inducing cancer cell apoptosis and thus can be considered as a potential candidate agent for treatment of cancer.
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