ReviewNature reviews. Urology2012
The hemodynamic approach to evaluating adolescent varicocele.
Review in Nature reviews. Urology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Surgical approaches to varicocele: a systematic review and network meta-analysis.Asian journal of andrology · 2025Pooled it
- Is Varicocele Truly Unilateral? Contralateral Involvement and Bilateral Testicular Effects in Male Infertility: A Narrative Review.Journal of personalized medicine · 2026Review
- Clinical evaluation and comprehensive management strategies for adolescent varicocele.Pediatric surgery international · 2025Review
- Management and Treatment of Varicocele in Children and Adolescents: An Endocrinologic Perspective.Journal of clinical medicine · 2019Review
- Clinical grading and color Doppler ultrasonography-based grading of varicocele: how compatible are the two grading systems?World journal of urology · 2019Article
- Best practice in the diagnosis and treatment of varicocele in children and adolescents.Therapeutic advances in urology · 2018Review
- Adolescent varicocele: limited indications for treatment during puberty and adolescence.Translational andrology and urology · 2014Review
- My indications for treatment of the adolescent varicocele (and why?).Translational andrology and urology · 2014Review
- Relationship of Clinical and Ultrasonographic Grading of Varicocele with Semen Analysis Profile and Testicular Volume.Journal of reproduction & infertilityArticle
- Doppler Ultrasonography - An Important Tool in Managing Patients With Varicocele and Secondary Infertility.In vivo (Athens, Greece)Article
- Varicoceles in the pediatric population: Diagnosis, treatment, and outcomes.Canadian Urological Association journal = Journal de l'Association des urologues du CanadaReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During adolescence, the risk of developing a varicocele increases. Prevalence is less than 1% in boys aged younger than 10 years, but approaches that of the general adult population (about 15%) during puberty. For adolescent males with varicoceles, surgical risk factors have not yet been clearly delineated and clinical severity correlates poorly with prognosis. Fortunately, the widespread use of Doppler ultrasonography is transforming the diagnostic work-up for this demographic. A continuous reflux detected by color Doppler ultrasound (CDUS) is thought to have a negative prognostic value and evidence suggests that a peak retrograde flow above 38 cm per second is a powerful predictor of lack of spontaneous improvement in adolescent patients with ≥ 20% asymmetry between testes. CDUS also enables the detection of varicocele resulting from reflux in the deferential vein adjunctive to a refluxing internal spermatic vein; a causality that accounts for approximately 15% of cases. In addition to a diagnostic role, hemodynamic parameters can be used to predict the risk of persistence or worsening asymmetry. Although further studies are necessary to validate single parameters, it seems that the more severe the reflux, the greater the likelihood that the patient will develop testicular asymmetry.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.