Evidence map›Paper›PMID 22450485›Full record

ReviewThe Journal of general physiology2012

Intracellular calcium movements during excitation-contraction coupling in mammalian slow-twitch and fast-twitch muscle fibers.

Stephen M Baylor, Stephen Hollingworth

Open access · bronzeAbstract readReview
In one paragraph

Review in The Journal of general physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 113 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Reactive oxygen species in the pathogenesis of sarcopenia.Free radical biology & medicine · 2025
    Review
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  8. Article
  9. DNA Methylation in the Adaptive Response to Exercise.Sports medicine (Auckland, N.Z.) · 2024
    Review
  10. Article
  11. Targeting mitochondrial CaThe Journal of physiology · 2024
    Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Stephen M BaylorDepartment of Physiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Stephen Hollingworth
University of Pennsylvania · US

Funding

Intracellular calcium signaling in normal and diseased mammalian skeletal muscle R01GM086167 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI BAYLOR, STEPHEN M. · 2008 to 2011
$1.3M
NIGMS NIH HHS GM 086167NIGMS NIH HHS R01 GM086167
6 · The paper itself

Abstract

In skeletal muscle fibers, action potentials elicit contractions by releasing calcium ions (Ca(2+)) from the sarcoplasmic reticulum. Experiments on individual mouse muscle fibers micro-injected with a rapidly responding fluorescent Ca(2+) indicator dye reveal that the amount of Ca(2+) released is three- to fourfold larger in fast-twitch fibers than in slow-twitch fibers, and the proportion of the released Ca(2+) that binds to troponin to activate contraction is substantially smaller.

Indexed as

Action PotentialsAnimalsCalciumCalcium SignalingExcitation Contraction CouplingHumansMuscle Fibers, Fast-TwitchMuscle Fibers, Slow-TwitchSarcoplasmic ReticulumCalcium

Identifiers

PMID22450485
PMCPMC3315149
OpenAlexW2154797839

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.