ReviewBiochimica et biophysica acta2012
Protein modification by aldehydophospholipids and its functional consequences.
Review in Biochimica et biophysica acta, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- Oxidised phosphatidylcholine induces sarcolemmal ceramide accumulation and insulin resistance in skeletal muscle.Diabetologia · 2024Article
- The Chemical Reactivity of Membrane Lipids.Chemical reviews · 2024Review
- Impact of Truncated Oxidized Phosphatidylcholines on Phospholipase AInternational journal of molecular sciences · 2023Article
- Surface Active Salivary Metabolites Indicate Oxidative Stress and Inflammation in Obstructive Sleep Apnea.Allergy, asthma & immunology research · 2023Article
- Pain Control by Targeting Oxidized Phospholipids: Functions, Mechanisms, Perspectives.Frontiers in endocrinology · 2020Review
- "Redox lipidomics technology: Looking for a needle in a haystack".Chemistry and physics of lipids · 2019Review
- Lipoxidation and cancer immunity.Redox biology · 2019Review
- Effects of Phenelzine Administration on Mitochondrial Function, Calcium Handling, and Cytoskeletal Degradation after Experimental Traumatic Brain Injury.Journal of neurotrauma · 2019Article
- Macrophage phenotype and bioenergetics are controlled by oxidized phospholipids identified in lean and obese adipose tissue.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Antinociception by the anti-oxidized phospholipid antibody E06.British journal of pharmacology · 2018Article
- NaFrontiers in molecular neuroscience · 2018Article
- How Does Membrane Oxidation Affect Cell Delivery and Cell Killing?Trends in biotechnology · 2017Article
- Inflammatory pain control by blocking oxidized phospholipid-mediated TRP channel activation.Scientific reports · 2017Article
- Oxidized Phospholipids Inhibit the Formation of Cholesterol-Dependent Plasma Membrane Nanoplatforms.Biophysical journal · 2016Article
- Protein lipoxidation: Detection strategies and challenges.Redox biology · 2015Review
- Physical damage on giant vesicles membrane as a result of methylene blue photoirradiation.Biophysical journal · 2014Article
- Effects of oxidized phospholipids on gene expression in RAW 264.7 macrophages: a microarray study.PloS one · 2014Article
- Interaction of aldehydes derived from lipid peroxidation and membrane proteins.Frontiers in physiology · 2013Review
- Demonstration of HNE-related aldehyde formation via lipoxygenase-catalyzed synthesis of a bis-allylic dihydroperoxide intermediate.Chemical research in toxicology · 2013Article
- Toxicity of oxidized phospholipids in cultured macrophages.Lipids in health and disease · 2012Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phospholipid aldehydes represent a particular subclass of lipid oxidation products. They are chemically reactive and can form Schiff bases with proteins and aminophospholipids. As chemically bound molecular entities they modulate the functional properties of biomolecules in solution and the surface of supramolecular systems including plasma lipoproteins and cell membranes. The lipid-protein and lipid-lipid conjugates may be considered the active primary platforms that are responsible for the biological effects of aldehydophospholipids, e.g. receptor binding, cell signaling, and recognition by the immune system. Despite the fact that aldehydophospholipids are covalently associated, they are subject to exchange between nucleophiles since their imine conjugates are not stable. As a consequence, aldehydophospholipids exist in a dynamic equilibrium between different "states" depending on the lipid and protein environment. Aldehydophospholipids may also contribute to the systemic administration and activity of oxidized phospholipids by inducing release of microparticles by cells. These effects are lipid-specific. Future studies should help clarify the mechanisms and consequences of these membrane-associated effects of "phospholipid stress". This article is part of a Special Issue entitled: Oxidized phospholipids-their properties and interactions with proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.