ArticleBone2012
Age and sex differences in tibia morphology in healthy adult Caucasians.
Article in Bone, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- The anterior offset of the standard entry point for tibial intramedullary nails: A transparent 3D-CT image based analysis.Journal of orthopaedics · 2025Article
- Improving the identification of bone-specific physical activity using wrist-worn accelerometry: A cross-sectional study in 11-12-year-old Australian children.European journal of sport science · 2024Article
- Off-the-Shelf Tibial Cone Sizes May Not Accommodate All Patients' Bone Morphology and May Lead to Cortical Breaches in Revision Total Knee Arthroplasty: A 3D Modeling Study.Arthroplasty today · 2024Article
- Influence of femoral bowing on stress distribution of the proximal femur: a three-dimensional finite element analysis.Journal of orthopaedic surgery and research · 2023Article
- Sex differences in the effect of diet, obesity, and exercise on bone quality and fracture toughness.Bone · 2021Article
- Cortical and medullary morphology of the tibia.Anatomical record (Hoboken, N.J. : 2007) · 2021Article
- Proximal tibial morphology and risk of posterior tibial cortex impingement in patients with AA-sized Oxford unicompartmental knee arthroplasty tibial implants.Journal of orthopaedic surgery and research · 2020Article
- Sex differences in bone density, geometry, and bone strength of competitive soccer players.Journal of musculoskeletal & neuronal interactions · 2020Article
- pQCT bone geometry and strength: population epidemiology and concordance in Australian children aged 11-12 years and their parents.BMJ open · 2019Article
- Article
- Differences of bone mineral mass, volumetric bone mineral density, geometrical and structural parameters and derived strength of the tibia between premenopausal and postmenopausal women of different age groups: a peripheral Quantitative Computed Tomography (pQCT) study.Journal of musculoskeletal & neuronal interactions · 2016Article
- Age-related changes in trabecular and cortical bone microstructure.International journal of endocrinology · 2013Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
unlabelledVariability in peripheral Quantitative Computed Tomography (pQCT) measurement sites limits direct comparisons of results between studies. Further, it is unclear what estimates of bone strength are most indicative of changes due to aging, disease, or interventions. The purpose of this study was to examine age group and sex differences in tibia morphology. Additional purposes of this study were to determine which tibia site or sites are most sensitive for detecting age and sex differences.
methodsSelf-identifying Caucasian men (n=55) and women (n=59) ages 20-59 years and separated by decades had their non-dominant tibias measured with pQCT (Stratec XCT 3000) at every 10% of the limb length from 5% to 85% (distal to proximal). Volumetric BMD and BMC of the total, cortical and trabecular bone were determined, as well as periosteal (PeriC) and endosteal (EndoC) circumferences, and cortical thickness (CTh).
resultsThere were significant (p<0.01) site effects for all BMC, vBMD, PeriC and EndoC measures. Large sex differences (men>women) in Tot.BMC (21-28%) were paralleled by differences in Cort.BMC (21-25%) (p<0.01). Site∗sex interaction effects were significant (p<0.05) for BMC (peak sex difference: 5%, 15%, 25%, 85% sites) and circumference (peak sex difference: 65% site) variables. CTh and total vBMD were lowest (p<0.05) in 50-59 year group, and EndoC was highest in the 50-59 year group. Site∗age interactions existed for Cort.vBMD, Tot.BMC (85% site), and EndoC (25%, 35%, 55%-85% sites). Correcting for bone free lean body mass (BFLBM) greatly reduced sex differences, eliminating sex∗site interaction effects, but sex main effects remained significant. Correcting for BFLBM did not eliminate age effects.
conclusionThe magnitude of age and sex differences in tibia variables varied by measurement site demonstrating the need for standardization of measurement sites.
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