ArticleVaccine2012
Parental and societal values for the risks and benefits of childhood combination vaccines.
Article in Vaccine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 6 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- The Value(s) of Vaccination: Building the Scientific Evidence According to a Value-Based Healthcare Approach.Frontiers in public health · 2022Pooled it
- Vaccine preferences driving vaccine-decision making of different target groups: a systematic review of choice-based experiments.BMC infectious diseases · 2021Pooled it
- Individual Preferences for Child and Adolescent Vaccine Attributes: A Systematic Review of the Stated Preference Literature.The patient · 2017Pooled it
- Valuing Meta-Health Effects for Use in Economic Evaluations to Inform Reimbursement Decisions: A Review of the Evidence.PharmacoEconomics · 2017Pooled it
- Discrete choice experiments in health economics: a review of the literature.PharmacoEconomics · 2014Pooled it
- Risk as an attribute in discrete choice experiments: a systematic review of the literature.The patient · 2014Pooled it
- Estimating the Value of Combination Vaccines: A Methodological Framework.PharmacoEconomics · 2026Review
- The Value of Combination Vaccines in Children and Adults: More than the Sum of Their Parts.PharmacoEconomics · 2026Article
- Physician Preferences for Universal Routine Depression Screening for Adolescents in Primary Care.JAMA network open · 2025Article
- Longitudinal association between parents' reported vaccination program preferences and children's actual immunization patterns in Shanghai, China.BMC public health · 2025Article
- Public willingness to receive chlamydia, gonorrhea, syphilis, and trichomoniasis vaccines: a scoping review.BMC health services research · 2023Article
- Better adherence to childhood Haemophilus influenzae type b vaccination with combination vaccines compared to single-antigen vaccines: Evidence from China.Journal of global health · 2023Article
- Preferences for Sexually Transmitted Infection and Cancer Vaccines in the United States and in China.Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research · 2023Article
- Article
- Parental preferences for the procedural sedation of children in dentistry: a discrete choice experiment.Frontiers in pediatrics · 2023Article
- Parental refusal and hesitancy of vaccinating children against COVID-19: Findings from a nationally representative sample of parents in the U.S.Preventive medicine · 2022Article
- Review
- Identifying the impact of social influences in health-related discrete choice experiments.PloS one · 2022Article
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- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundNew combination vaccines reduce the number of injections needed for immunization. However, possible drawbacks include higher prices, extra doses of vaccine antigens and increased minor adverse events. Our objective was to measure parental and societal values for attributes of childhood combination vaccines.
methodsWe conducted a discrete choice experiment using an online survey of adults administered by Knowledge Networks. Values were measured for attributes of combination vaccines for a hypothetical child aged 6 months: (1) number of injections, (2) extra dose of hepatitis B vaccine, (3) 20% higher chance of fever, (4) community-level immunization coverage of 2-year-olds of 90% or 80%, and (5) cost per visit. Logistic regression with generalized estimating equations was used to analyze the value of different attributes and generate a marginal willingness-to-pay for a change in attribute level.
resultsThe response rate was 64% (N=558). Most respondents were parents (63%) and most respondents agreed that combination vaccines were safe (77%). Respondents were willing to pay $7.68 to avoid an injection (compared to $9.94 when looking at parents only). However, respondents were willing to pay $41.57 to avoid higher risk of fever after one set of immunizations (10% versus 30%) and $65.42 for higher immunization coverage rates. These results were very similar for parents only. There was no significant preference to avoid an extra dose of hepatitis B vaccine.
conclusionsRespondents were willing to pay larger amounts to avoid increased risk of minor adverse events and to increase community-level immunization coverage than to avoid injections. These values should be taken into account when determining the risks and benefits of combination vaccines.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.